Ignite Creation Date:
2024-05-06 @ 7:32 PM
Last Modification Date:
2024-10-26 @ 3:08 PM
Study NCT ID:
NCT06042296
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-09-18
First Post:
2023-09-10
Brief Title:
Expression of CD44 PCNA and E-cadherin in Pterygium Tissue
Sponsor:
Balikesir University
Organization:
Balikesir University
Study Overview
Official Title:
Expression of CD44 PCNA and E-cadherin in Pterygium Tissue
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Purpose Pterygium is a common ocular surface disease defined by fibrovascular conjunctival growth extending onto the cornea Its pathogenesis remains unclear In severe cases it may extend into the central cornea inducing irregular corneal astigmatism and causing loss of vision CD44 phagocytic glycoprotein-1 is involved in the organization of certain cellular processes for instance cell adhesion division and migration by binding with its main ligand hyaluronic acid Proliferating cell nuclear antigen PCNA is a proliferation marker in the nucleus E-cadherin is a calcium-dependent transmembrane glycoprotein that plays a significant role in the protection of tissue integrity and cell-to-cell adhesion This study aimed to determine the role of CD44 proliferating cell nuclear antigen PCNA and E-cadherin in pterygium formation and recurrence
Detailed Description:
Methods60 patients with pterygium will be enrolled in the study and conjunctival samples will be collected from 30 patients to form the control group CD44 PCNA and E-cadherin expressions in surgically removed pterygium will be compared with tissue samples from normal control group
IBM SPSS statistical software version 260 will be used for statistical analyses
IBM SPSS statistical software version 260 will be used for statistical analyses
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None