Ignite Creation Date:
2024-05-06 @ 7:39 PM
Last Modification Date:
2024-10-26 @ 3:10 PM
Study NCT ID:
NCT06081946
Status:
RECRUITING
Last Update Posted:
2024-01-29
First Post:
2023-10-02
Brief Title:
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Investigation of the Effects of Sleep Provocations on Itch and Pain Sensitivity
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In This experiment the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch
To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them
To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein CRP levels from blood samples
To correlate the anxiety and depression scores evaluated through questionnaires with itch and pain sensitivity and evaluate how they are affected by sleep fragmentation
To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them
To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein CRP levels from blood samples
To correlate the anxiety and depression scores evaluated through questionnaires with itch and pain sensitivity and evaluate how they are affected by sleep fragmentation
Detailed Description:
Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals Furthermore there is a lack of efficient treatment options for chronic itch
Poor sleep is a common companion of itch and is often reported by patients with chronic itch Poor sleep is often characterized by nightly awakenings and troubles falling asleep This is a significant problem as poor sleep in general is associated with lowered quality of life While previous research has already established the negative impact of itch on sleep it is yet to be studied whether the opposite tendency might be true as well Knowledge about patients with chronic pain has shown that poor sleep can increase the sensitivity to pain and inflammation and this tendency can also be observed in healthy participants after experimental sleep provocations
Therefore the investigators wish to investigate how sleep provocations affect markers of itch in healthy participants
Poor sleep is a common companion of itch and is often reported by patients with chronic itch Poor sleep is often characterized by nightly awakenings and troubles falling asleep This is a significant problem as poor sleep in general is associated with lowered quality of life While previous research has already established the negative impact of itch on sleep it is yet to be studied whether the opposite tendency might be true as well Knowledge about patients with chronic pain has shown that poor sleep can increase the sensitivity to pain and inflammation and this tendency can also be observed in healthy participants after experimental sleep provocations
Therefore the investigators wish to investigate how sleep provocations affect markers of itch in healthy participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None