Ignite Creation Date:
2024-05-06 @ 7:45 PM
Last Modification Date:
2024-10-26 @ 3:13 PM
Study NCT ID:
NCT06125665
Status:
RECRUITING
Last Update Posted:
2023-11-14
First Post:
2023-11-05
Brief Title:
Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Impacts of Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery A Prospective Randomized Double Blinded Trial
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to evaluate the usefulness of adding aminophylline to dexmedetomidine intravenous infusion intraoperatively on oxygenation and lung mechanics in chronic obstructive pulmonary disease COPD morbidly obese patients undergoing bariatric surgery
Detailed Description:
Bariatric surgery is considered the most effective treatment for patients suffering from morbid obesity as it results in maintained loss of weight and clear impact on the comorbidities related to obesity However despite the advantages of anesthesia it can have detrimental effects on the recovery of obese patients who have a high prevalence of respiratory conditions and sleep disorders
Obesity is usually related to other respiratory diseases such as asthma chronic obstructive pulmonary disease COPD According to a meta-analysis encompassing more than 300000 adult patients obesity and asthma were interlinked and as BMI increased a higher risk of asthma was noticed
The use of dexmedetomidine infusion in morbid obese patients was assessed by many clinical trials They revealed that the use of dexmedetomidine has the same analgesic effect as the use of fentanyl with greater hemodynamic stability obtained with the use of dexmedetomidine Dexmedetomidine has the advantage of having no respiratory depressant effect Also it has an amnestic effect Dexmedetomidine does not affect the sleep pattern and maintains the airway patency
Aminophylline is a compound of theophylline with ethylenediamine and most common uses in the airway obstruction such as asthma and COPD primarily for its bronchodilating and central nervous stimulating effects However emprical evidence suggests that aminophylline as an adenosine antagonist can improve the recovery time from general anesthesia
Obesity is usually related to other respiratory diseases such as asthma chronic obstructive pulmonary disease COPD According to a meta-analysis encompassing more than 300000 adult patients obesity and asthma were interlinked and as BMI increased a higher risk of asthma was noticed
The use of dexmedetomidine infusion in morbid obese patients was assessed by many clinical trials They revealed that the use of dexmedetomidine has the same analgesic effect as the use of fentanyl with greater hemodynamic stability obtained with the use of dexmedetomidine Dexmedetomidine has the advantage of having no respiratory depressant effect Also it has an amnestic effect Dexmedetomidine does not affect the sleep pattern and maintains the airway patency
Aminophylline is a compound of theophylline with ethylenediamine and most common uses in the airway obstruction such as asthma and COPD primarily for its bronchodilating and central nervous stimulating effects However emprical evidence suggests that aminophylline as an adenosine antagonist can improve the recovery time from general anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None