Ignite Creation Date:
2024-05-06 @ 7:50 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06151990
Status:
RECRUITING
Last Update Posted:
2023-11-30
First Post:
2023-11-13
Brief Title:
Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine pattern and frequency of dyslipoproteinemia in patients with newly diagnosed juvenile SLE and to assess effect of disease activity on lipid profile of patients with juvenile SLE
Detailed Description:
Systemic lupus erythematosus SLE is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies against self-antigens leading to inflammatory damage of many target organs including the skin joints kidneys blood cells blood vessels and the central nervous systemPremature atherosclerosis has been recognized as an important issue for patients with SLE since the mid-1970s Among the traditional risk factors of atherosclerosis a history of smoking diabetes hypertension and abnormal lipid profile have been shown to be important 7 In patients with juvenile SLE smoking diabetes and uncontrolled hypertension are not common and therefore abnormal lipid profiles may be the most important risk factorThe lipid profile of both children and adults with SLE is the result of a combination of the influences of active disease therapies and genetics The best way to determine the maximal potential effect of disease activity itself would be to examine patients at the time of presentation of SLE when they are likely to have high disease activity but no effect of corticosteroid therapyStudies in patients with active SLE suggested that there is a distinct pattern of lipid abnormalities of increased very low-density lipoprotein VLDL and triglycerides and decreased high-density lipoprotein HDL-C cholesterol and apolipoprotein A1 levels active SLE pattern
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None