Ignite Creation Date:
2024-05-06 @ 7:50 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06154824
Status:
RECRUITING
Last Update Posted:
2024-01-26
First Post:
2023-11-20
Brief Title:
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In This experiment the investigators would like to test following hypotheses
repetitive cutaneous administration of pruritogens will lead to a more robust and longer lasting itch sensation compared with a single application The aim of this project is to investigate a new itch model based on repetitive administration of three different pruritogens histamine histaminergic itch cowhage and BAM 8-22 non-histaminergic itch
repetitive cutaneous administration of pruritogens will lead to a more robust and longer lasting itch sensation compared with a single application The aim of this project is to investigate a new itch model based on repetitive administration of three different pruritogens histamine histaminergic itch cowhage and BAM 8-22 non-histaminergic itch
Detailed Description:
Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals Furthermore there is a lack of efficient treatment options for chronic itch In order to mimic a clinical itch condition as presented in patients the aim of the project is to investigate a new itch model based on repetitive administration of three different pruritogens histamine histaminergic itch cowhage and BAM 8-22 non-histaminergic itch The hypothesis is that repetitive cutaneous administration of pruritogens will lead to a more robust and longer-lasting itch sensation compared with a single application This proposal for a new itch model could better mimic clinical itch conditions and be used to investigate fundamental mechanisms new anti-pruritic drugs and their possible mechanisms of action
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None