Ignite Creation Date:
2024-05-06 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06150690
Status:
RECRUITING
Last Update Posted:
2023-11-29
First Post:
2019-09-12
Brief Title:
Study on Pancreatic Islets in Patients Undergoing Partial Pancreatectomy PRECISE
Sponsor:
German Diabetes Center
Organization:
German Diabetes Center
Study Overview
Official Title:
Study on the Function of Insulin-producing Beta Cells in the Human Pancreas
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PRECISE
Brief Summary:
The study investigates the mechanisms underlying the pathogenesis of diabetes by examining structural and functional properties of islets of Langerhans in pancreas specimen from patients undergoing partial pancreatectomy
Detailed Description:
The study aims at elucidating the mechanisms underlying the pathogenesis of diabetes In particular the study focusses on detailed analyses of morphological and functional properties of pancreatic isletsinsulin-producing beta cells in order to identify diabetes-associated alterations on cellular and molecular levels To directly address the role of the endocrine and exocrine pancreas in the complex process of diabetes development the examinations are performed in samples of human pancreatic tissue To this end biopsy specimen of pancreas and visceral adipose tissue are collected from patients with or without diabetes who undergo partial pancreatectomy The samples are analysed for morphological alterations eg size and distribution of pancreatic islets and beta cells size of adipocytes and functional changes eg gene expression patterns as assessed from beta-cell derived RNA In addition patient characteristics such as age and disease duration are documented and clinical data including fasting concentrations of blood glucose insulin and free fatty acids are collected Specific diabetes-associated alterations of pancreatic islet beta cells are assessed by associating variables of glucose- and lipid-homeostasis with parameters of beta cell function The expected outcomes of the study will contribute to improve our knowledge of the so far largely unknown molecular and cellular mechanisms involved in the pathogenesis of diabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None