Ignite Creation Date:
2024-05-06 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06162988
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-12-08
First Post:
2023-11-19
Brief Title:
PET Imaging of 68Ga-NOTA-H006 in Malignancy
Sponsor:
YiHui Guan
Organization:
Huashan Hospital
Study Overview
Official Title:
A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
5T4 also known as trophoblast glycoprotein is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian gastric and colorectal cancers Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages
Previously investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models Thus the aims of current study are to evaluate the distribution and dosimetry of this novel tracer and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors
Previously investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models Thus the aims of current study are to evaluate the distribution and dosimetry of this novel tracer and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None