Ignite Creation Date:
2024-05-06 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06168357
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-12-13
First Post:
2023-12-05
Brief Title:
Role of Abbreviated MRI in Follow-up of Hepatocellular Carcinoma
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Role of Abbreviated MRI in Follow-up of Hepatocellular Carcinoma Following Locoregional Treatment
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Role of ADC value and DWI in abbreviated MRI compared to post-contrast CT in follow-up of HCC after TACE
Detailed Description:
Hepatocellular carcinoma HCC is the 5th most common cancer in the world and the most common in Egypt
Trans-arterial chemoembolization TACE is the treatment recommended for unresectable HCC according to Barcelona clinic liver cancer staging and is widely used
HCC is nourished only by the hepatic artery so TACE causes ischemia and coagulative necrosis However viable neoplastic tissue residual may be seen after TACE Assessment of post-TACE tumor response is important in determining treatment success and in guiding future therapy
Many studies have assessed the diagnostic performance of multiphasic contrast-enhanced computed tomography CT and magnetic resonance imaging MRI in diagnosis of HCC with noted higher sensitivity of MRI compared to CT CT or MRI are recommended for assessment of response after treatment as well
Diffusion-weighted imaging DWI and apparent diffusion coefficient ADC are functional MRI techniques that detect signal changes in tissues due to water proton motion The intact membranes of viable tumor cells restrict water diffusion whereas necrotic tumor cells with disrupted cell membranes exhibit increased water diffusion and which differentiate the biological activity of HCC
Trans-arterial chemoembolization TACE is the treatment recommended for unresectable HCC according to Barcelona clinic liver cancer staging and is widely used
HCC is nourished only by the hepatic artery so TACE causes ischemia and coagulative necrosis However viable neoplastic tissue residual may be seen after TACE Assessment of post-TACE tumor response is important in determining treatment success and in guiding future therapy
Many studies have assessed the diagnostic performance of multiphasic contrast-enhanced computed tomography CT and magnetic resonance imaging MRI in diagnosis of HCC with noted higher sensitivity of MRI compared to CT CT or MRI are recommended for assessment of response after treatment as well
Diffusion-weighted imaging DWI and apparent diffusion coefficient ADC are functional MRI techniques that detect signal changes in tissues due to water proton motion The intact membranes of viable tumor cells restrict water diffusion whereas necrotic tumor cells with disrupted cell membranes exhibit increased water diffusion and which differentiate the biological activity of HCC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None