Ignite Creation Date:
2024-05-06 @ 7:52 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06166810
Status:
RECRUITING
Last Update Posted:
2023-12-12
First Post:
2023-12-04
Brief Title:
Capture of Healthy Gut Bacteria Associated to High Fiber Diet
Sponsor:
Institut National de Recherche pour lAgriculture lAlimentation et lEnvironnement
Organization:
Institut National de Recherche pour lAgriculture lAlimentation et lEnvironnement
Study Overview
Official Title:
In Silico and in Vitro Targeting of Healthy Gut Bacteria With Fiber Degrading Metabolic Potential
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
iTARGET
Brief Summary:
The role of the intestinal microbiota on health is now well recognised and diet is one of the factors influencing the maintenance of a healthy intestinal microbiota More specifically the consumption of fruit vegetables and cereals is associated with good health and in particular with an increase in the relative abundance of bacterial groups described as beneficial To date a large number of bacterial species in the intestinal microbiota have yet to be isolated and cultivated which limits the characterisation of their potential health benefits In order to isolate and cultivate these intestinal bacteria it is particularly relevant to recruit individuals with a high-fibre diet
Detailed Description:
Since two decades numerous studies have been performed to better understand the role of the gut microbiota in health and disease An imbalance in the intestinal microbiota known as dysbiosis is frequently described as a cause of many chronic diseases and metabolic dysfunctions in humans Among the factors that play an important role in maintaining this balance diet plays a predominant role More specifically the consumption of fruit vegetables and cereals is associated with good health and in particular with an increase in the relative abundance of bacterial groups described as beneficial Modulating the intestinal microbiota via the or directly by providing these beneficial bacteria next generation probiotics NGPs is therefore a possible promising approach for the prevention andor treatment of pathologies To date a large number of bacterial species in the intestinal microbiota have yet to be isolated and cultivated which limits the characterization of their potential health benefits Having strains that can be isolated and cultured is an essential step in phenotyping and characterization In order to isolate and cultivate these intestinal bacteria it is particularly important to recruit individuals with a high-fiber diet In this context a positive selection of donors based on their dietary profiles highly enriched in fiber is essential In this study we aim to identify in silico unprecedented potentially new beneficial gut bacteria and isolate culture and characterize these bacterial species for their potential We will take an innovative approach using culturomics tools guided by metagenomics to isolate them To do this we will collect the fecal samples of 10 healthy volunteers with a regular and diversified intake of fruit vegetables and cereals which encourage the growth of beneficial micro-organisms and increase the richness of the intestinal microbiota
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None