Ignite Creation Date:
2024-05-06 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06170307
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-12-14
First Post:
2023-12-11
Brief Title:
Left Atrial Function of COVID-19-recovered Patients During the Surge of Omicron Variants
Sponsor:
Haiyan Wang
Organization:
Qianfoshan Hospital
Study Overview
Official Title:
Assessment of Left Atrial Function of COVID-19-recovered Patients During the Surge of Omicron Variants by Two-dimensional Speckle Tracking Echocardiography
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to retrospectively analyze left atrial function in mild to moderate COVID-19-recovered patients The main questions it aims to answer are
Whether left atrial function is involved in patients with mild to moderate COVID-19 after recovery
What are the factors that may be associated with persistent heart-related symptoms including chest pain chest tightness palpitations shortness of breath or postural tachycardia in patients with mild to moderate COVID-19
Participants will undergo transthoracic echocardiography to obtain conventional ultrasound parameters two-dimensional strain parameters will been obtained through software post-processing and general clinical data and laboratory test results will been obtained
Whether left atrial function is involved in patients with mild to moderate COVID-19 after recovery
What are the factors that may be associated with persistent heart-related symptoms including chest pain chest tightness palpitations shortness of breath or postural tachycardia in patients with mild to moderate COVID-19
Participants will undergo transthoracic echocardiography to obtain conventional ultrasound parameters two-dimensional strain parameters will been obtained through software post-processing and general clinical data and laboratory test results will been obtained
Detailed Description:
The included patients who recovered from COVID-19 infection and healthy people underwent transthoracic echocardiography at the First Affiliated Hospital of Shandong First Medical University from December 20 2022 to January 20 2023 Routine data and two-dimensional strain parameters of transthoracic echocardiography of the study subjects were obtained
1 The echocardiographic examination was performed using a Epiq 7C ultrasound machine and images were acquired with the patient in left lateral decubitus using a 35-5 MHz transducer at a depth of 16 cm ECG was recorded and 3 consecutive cardiac cycles of each view were recorded during quiet breathing at 50-80 framessec All patients were subjected to conventional transthoracic echocardiography Speckle tracking echocardiography STE All measurements were taken following the American Society of Echocardiography ASE recommendations
2 Left atrial strain analysis was obtained using automated speckle tracking software The regions of interest were generated automatically and Left atrial endocardial border was manually adjusted when required Left atrial phases definition and Left atrial strain values were measured from the Left atrial longitudinal strain curve according to the European Association of Cardiovascular Imaging EACVIAmerican society of echocardiography ASE guidelines Global LV systolic strain was evaluated and the software automatically traced the contour of the endocardium at apical three four and two-chamber views
3 At the same time the general clinical data demographic characteristics electrocardiogram chest CT results troponin I hsTnI and brain natriol peptide levels on the day of echocardiographic examination were obtained through the hospital electronic medical record His system
4 Clinical follow-up was performed 12-18 months after the echocardiographic examination by phone and by electronic health record review We recorded 1 persistent cardiac symptoms 2 interval presentation to the emergency department or hospitalization with cardiac symptoms and 3 any major adverse cardiac event myocardial infarction stroke revascularization or death
1 The echocardiographic examination was performed using a Epiq 7C ultrasound machine and images were acquired with the patient in left lateral decubitus using a 35-5 MHz transducer at a depth of 16 cm ECG was recorded and 3 consecutive cardiac cycles of each view were recorded during quiet breathing at 50-80 framessec All patients were subjected to conventional transthoracic echocardiography Speckle tracking echocardiography STE All measurements were taken following the American Society of Echocardiography ASE recommendations
2 Left atrial strain analysis was obtained using automated speckle tracking software The regions of interest were generated automatically and Left atrial endocardial border was manually adjusted when required Left atrial phases definition and Left atrial strain values were measured from the Left atrial longitudinal strain curve according to the European Association of Cardiovascular Imaging EACVIAmerican society of echocardiography ASE guidelines Global LV systolic strain was evaluated and the software automatically traced the contour of the endocardium at apical three four and two-chamber views
3 At the same time the general clinical data demographic characteristics electrocardiogram chest CT results troponin I hsTnI and brain natriol peptide levels on the day of echocardiographic examination were obtained through the hospital electronic medical record His system
4 Clinical follow-up was performed 12-18 months after the echocardiographic examination by phone and by electronic health record review We recorded 1 persistent cardiac symptoms 2 interval presentation to the emergency department or hospitalization with cardiac symptoms and 3 any major adverse cardiac event myocardial infarction stroke revascularization or death
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None