Ignite Creation Date:
2024-05-06 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06177587
Status:
COMPLETED
Last Update Posted:
2023-12-20
First Post:
2023-12-08
Brief Title:
Multimarker Evaluation of Platelet Activity and Agregation in ACS
Sponsor:
Medical University of Warsaw
Organization:
Medical University of Warsaw
Study Overview
Official Title:
Multimarker Evaluation of Platelet Activity and Agregation in Patients Presenting With Acute Coronary Syndrome Prospective Observational Study
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with acute coronary syndrome ACS who undergo percutaneous coronary intervention PCI are at a higher risk of ischemic complications even while receiving proper dual antiplatelet therapy For this reason identifying high-risk patients and personalizing treatment according to their profile could be a solution towards improving the efficacy and safety of the antiplatelet treatment
This is a prospective single centre study analyzing correlations and clinical outcomes of patients in relation to biomarkers in acute coronary syndrome The blood samples were collected from patients admitted to the hospital with a diagnosis of ACS and treated with dual antiplatelet therapy
The blood samples were collected from each patient within the first 24 hours after the admission for acute coronary syndrome ACS and after 72 hours of hospitalization
This is a prospective single centre study analyzing correlations and clinical outcomes of patients in relation to biomarkers in acute coronary syndrome The blood samples were collected from patients admitted to the hospital with a diagnosis of ACS and treated with dual antiplatelet therapy
The blood samples were collected from each patient within the first 24 hours after the admission for acute coronary syndrome ACS and after 72 hours of hospitalization
Detailed Description:
In this prospective single-center observational study adult patients meeting the inclusionexclusion criteria were included Subjects enrolled at the Invasive Cardiology Unit of the 1st Department of Cardiology Medical University of Warsaw Poland were cathegorized into three arms 1 treated with aspirin and clopidogrel 2 treated with aspirin and ticagrelor 3 treated with aspirin and prasugrel In all three groups subjects first obtained the loading dose of the drug and thereafter they received a fixed daily dose
Blood samples were collected form each patient at two time-points during the first 24 hours from hospital admission and after 72 hours following hospital admission The parameters measured included selected platelet-derived microRNAs prticles immature platelet fraction IPF and platelet microvesicles comncentration Platelet reactivity was established using Multiplate Analyzer Roche
Blood samples were collected form each patient at two time-points during the first 24 hours from hospital admission and after 72 hours following hospital admission The parameters measured included selected platelet-derived microRNAs prticles immature platelet fraction IPF and platelet microvesicles comncentration Platelet reactivity was established using Multiplate Analyzer Roche
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None