Ignite Creation Date:
2024-05-06 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06179680
Status:
RECRUITING
Last Update Posted:
2023-12-22
First Post:
2023-11-23
Brief Title:
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimers Disease
Sponsor:
IRCCS Policlinico S Donato
Organization:
IRCCS Policlinico S Donato
Study Overview
Official Title:
Quantification of White Matter Hyperintensities in Subjects With Amnestic Mild Cognitive Impairment or Alzheimers Disease
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment aMCI or Alzheimers disease
Objective
The primary objective of the study is to quantify the extent and distribution of white matter hyperintensities in the brains of individuals diagnosed with amnestic mild cognitive impairment or Alzheimers disease White matter hyperintensities are areas of increased signal intensity observed on brain magnetic resonance imaging MRI scans often associated with various cognitive disorders
Importance
Understanding the presence and severity of white matter hyperintensities in individuals with aMCI or Alzheimers disease is crucial for several reasons These abnormalities may serve as potential biomarkers aiding in the early diagnosis and prognosis of cognitive disorders Additionally quantifying white matter hyperintensities could contribute to a better comprehension of the underlying neuropathological processes associated with these conditions
Methods
The study employs advanced imaging techniques likely including MRI to capture and analyze white matter hyperintensities in the brains of participants with amnestic mild cognitive impairment or Alzheimers disease The quantification process involves precise measurement and mapping of these hyperintense regions
Participants
The study involves individuals diagnosed with amnestic mild cognitive impairment or Alzheimers disease Participants will undergo neurological assessments and imaging procedures to facilitate the accurate measurement of white matter hyperintensities
Expected outcomes
Researchers anticipate that the quantification of white matter hyperintensities will provide valuable insights into the progression of cognitive disorders The results may contribute to the development of more targeted and effective diagnostic and therapeutic interventions for individuals with amnestic mild cognitive impairment or Alzheimers disease
Conclusion
This study represents a significant step toward enhancing our understanding of the neuropathological changes associated with amnestic mild cognitive impairment and Alzheimers disease By focusing on the quantification of white matter hyperintensities researchers aim to uncover potential markers for early detection and monitoring of these cognitive disorders
Objective
The primary objective of the study is to quantify the extent and distribution of white matter hyperintensities in the brains of individuals diagnosed with amnestic mild cognitive impairment or Alzheimers disease White matter hyperintensities are areas of increased signal intensity observed on brain magnetic resonance imaging MRI scans often associated with various cognitive disorders
Importance
Understanding the presence and severity of white matter hyperintensities in individuals with aMCI or Alzheimers disease is crucial for several reasons These abnormalities may serve as potential biomarkers aiding in the early diagnosis and prognosis of cognitive disorders Additionally quantifying white matter hyperintensities could contribute to a better comprehension of the underlying neuropathological processes associated with these conditions
Methods
The study employs advanced imaging techniques likely including MRI to capture and analyze white matter hyperintensities in the brains of participants with amnestic mild cognitive impairment or Alzheimers disease The quantification process involves precise measurement and mapping of these hyperintense regions
Participants
The study involves individuals diagnosed with amnestic mild cognitive impairment or Alzheimers disease Participants will undergo neurological assessments and imaging procedures to facilitate the accurate measurement of white matter hyperintensities
Expected outcomes
Researchers anticipate that the quantification of white matter hyperintensities will provide valuable insights into the progression of cognitive disorders The results may contribute to the development of more targeted and effective diagnostic and therapeutic interventions for individuals with amnestic mild cognitive impairment or Alzheimers disease
Conclusion
This study represents a significant step toward enhancing our understanding of the neuropathological changes associated with amnestic mild cognitive impairment and Alzheimers disease By focusing on the quantification of white matter hyperintensities researchers aim to uncover potential markers for early detection and monitoring of these cognitive disorders
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None