Ignite Creation Date:
2024-05-06 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06177613
Status:
RECRUITING
Last Update Posted:
2024-06-14
First Post:
2023-12-11
Brief Title:
Benefit of Early Intrauterine Transfer of Blank Culture Medium Prior to Transfer of a Thawed Embryo From 1st in Vitro Fertilization
Sponsor:
Centre Hospitalier Universitaire de Nīmes
Organization:
Centre Hospitalier Universitaire de Nīmes
Study Overview
Official Title:
Benefit of Early Intrauterine Transfer of Blank Culture Medium Prior to Transfer of a Thawed Embryo From 1st in Vitro Fertilization - Randomized Single-blind Multicenter Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TRABLAN
Brief Summary:
Despite technical advances in Medically Assisted Reproduction AMP the success of fertility treatments is sometimes limited by embryo implantation failure The coordinated development of the embryo and the uterine endometrium requires close communication between the maternal tissue and the embryo In in vitro fertilization IVF embryo transfer generally takes place between the 2nd D2 and the 6th D6 day following oocyte fertilization Recent studies have shown the advantages of sequential transfer transfer of an embryo on D2D3 followed by the transfer of another embryo on D5D6 with higher implantation and clinical pregnancy rate fewer miscarriages more live births and yet no increase in multiple pregnancies However the American Society for Reproductive Medicine recommendations continue to prioritize the transfer of a single embryo for all patients aged under 38 To improve pregnancy rates for patients having a single embryo transferred the study investigators wish to carry out on blank transfer based on the principle of sequential transfer The study investigators hypothesize that a culture medium placed in the uterus before the time of embryo transfer will modify immune tolerance The study will test whether transferring the same culture medium in an equivalent quantity as during the real transfer into the uterus 23 days before the embryo transfer will improve tolerance to this foreign medium and therefore embryo implantation The aim of this study is thus to evaluate the impact of a blank transfer with culture medium alone on the results of frozen embryo transfers FET from IVF
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None