Ignite Creation Date:
2024-05-06 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06177886
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-12-20
First Post:
2023-12-02
Brief Title:
Acute Kidney Injury in Pediatric Polytrauma Patients at Assiut University Trauma Unit A Cross-Sectional Study on Incidence and Predictive Risk Factors
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Incidence and Predictive Risk Factors of Acute Kidney Injury in Pediatric Polytrauma Patients Admitted to Assiut University Trauma Unit a Cross-sectional Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized pediatric patients and identify the risk and severity of AKI The results would aid the emergency physicians in the early identification of those at risk of AKI to establish a resuscitation strategy that aims at preventing AKI
Detailed Description:
Trauma is a leading cause of morbidity and mortality throughout Africa and the leading cause of mortality worldwide for children and young adults 5-29 years of age
Organ failure including AKI is the third leading cause of mortality in trauma patients after bleeding and brain injuries
Trauma patients are at risk of AKI caused by renal hypoperfusion secondary to haemorrhagic shock rhabdomyolysis direct renal injury abdominal compartment syndrome or the nephrotoxic effects of therapies
The majority of trauma-based AKI studies worldwide have looked at critically ill adult trauma patients and these report highly variable AKI rates ranging 1-50
Though pediatric trauma studies on AKI are scarce a California study suggests 13 of pediatric post-traumatic rhabdomyolysis patients experience AKI
Acute kidney injury AKI is described as a spectrum of abruptly compromised renal functions that result in impaired balance of fluid electrolytes and waste products It is recognized as an increasingly common cause of morbidity and mortality in children
AKI is defined according to The Kidney Disease Improving Global Outcomes KDIGO Clinical Practice Guidelines as any of the following increase in serum creatinine by 03 mgdL within 48 h or increase in serum creatinine to 15 times baseline which is known or presumed to have occurred within the prior seven days or urine volume 05ml kg h for 6 hr
Preventive measures for AKI are currently the mainstay of non-dialytic AKI management They include the use of a pediatric early warning score for early detection of AKI preparation to provide for volume resuscitation in patients with hypovolemia related oliguria and halting the administration of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in such patients until their volume status is stabilized Using appropriate nephrotoxic drug doses ie vancomycin andor contrast media to reduce harm to the kidneys
RRT is the most effective way of managing severe AKI Peritoneal dialysis has shown as an effective adjuvant treatment for achieving a negative fluid balance decreasing mechanical ventilation duration and reducing electrolyte disturbances There is currently no specific effective treatment after the occurrence of established AKI Early detection and prevention of AKI is essential
Organ failure including AKI is the third leading cause of mortality in trauma patients after bleeding and brain injuries
Trauma patients are at risk of AKI caused by renal hypoperfusion secondary to haemorrhagic shock rhabdomyolysis direct renal injury abdominal compartment syndrome or the nephrotoxic effects of therapies
The majority of trauma-based AKI studies worldwide have looked at critically ill adult trauma patients and these report highly variable AKI rates ranging 1-50
Though pediatric trauma studies on AKI are scarce a California study suggests 13 of pediatric post-traumatic rhabdomyolysis patients experience AKI
Acute kidney injury AKI is described as a spectrum of abruptly compromised renal functions that result in impaired balance of fluid electrolytes and waste products It is recognized as an increasingly common cause of morbidity and mortality in children
AKI is defined according to The Kidney Disease Improving Global Outcomes KDIGO Clinical Practice Guidelines as any of the following increase in serum creatinine by 03 mgdL within 48 h or increase in serum creatinine to 15 times baseline which is known or presumed to have occurred within the prior seven days or urine volume 05ml kg h for 6 hr
Preventive measures for AKI are currently the mainstay of non-dialytic AKI management They include the use of a pediatric early warning score for early detection of AKI preparation to provide for volume resuscitation in patients with hypovolemia related oliguria and halting the administration of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in such patients until their volume status is stabilized Using appropriate nephrotoxic drug doses ie vancomycin andor contrast media to reduce harm to the kidneys
RRT is the most effective way of managing severe AKI Peritoneal dialysis has shown as an effective adjuvant treatment for achieving a negative fluid balance decreasing mechanical ventilation duration and reducing electrolyte disturbances There is currently no specific effective treatment after the occurrence of established AKI Early detection and prevention of AKI is essential
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None