Ignite Creation Date:
2024-05-06 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06179368
Status:
RECRUITING
Last Update Posted:
2024-01-16
First Post:
2023-12-12
Brief Title:
Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Thyoid Dysfucntion Does it Affect the Short Term Outcome of Heptic Failure Patiens
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Liver plays an important role in the metabolism of thyroid hormones as it is the most important organ in the peripheral conversion of tetraiodothyronine T4 to triiodothyronine T3 by Type 1 deiodinase
Detailed Description:
In clinical terms cirrhosis is described as are either compensated or decompensated Decompensation means cirrhosis complicated by one or more of the following features jaundice ascites hepatic encephalopathy HE or bleeding varices Ascites is the usual first sign Hepatorenal syndrome hyponatremia and spontaneous bacterial peritonitis are also features of decompensation but in these patients ascites invariably occurs first Compensated cirrhotic patients have none of these features
The liver plays an important role in the metabolism of thyroid hormones as it is the most important organ in the peripheral conversion of tetraiodothyronine T4 to T3 by Type 1 deiodinase
T4 and T3 regulate the basal metabolic rate of all cells including hepatocytes and thereby modulate hepatic function The liver metabolizes the THS and regulates their systemic endocrine effects Thyroid diseases may perturb liver function liver disease modulates thyroid hormone metabolism and a variety of systemic diseases affect both the organs
The liver plays an important role in the metabolism of thyroid hormones as it is the most important organ in the peripheral conversion of tetraiodothyronine T4 to T3 by Type 1 deiodinase
T4 and T3 regulate the basal metabolic rate of all cells including hepatocytes and thereby modulate hepatic function The liver metabolizes the THS and regulates their systemic endocrine effects Thyroid diseases may perturb liver function liver disease modulates thyroid hormone metabolism and a variety of systemic diseases affect both the organs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None