Ignite Creation Date:
2024-05-06 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06185582
Status:
RECRUITING
Last Update Posted:
2023-12-29
First Post:
2023-11-20
Brief Title:
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In This experiment the investigators would like to test following hypotheses
the pain stimulation applied at the same time of a pruriceptive stimulus will decrease the itch perception Moreover also the effect of the cutaneous pain stimulus location same forearm of the pruriceptive stimulus versus the opposite forearm on histaminergic and non-histaminergic itch will be investigated
the pain stimulation applied at the same time of a pruriceptive stimulus will decrease the itch perception Moreover also the effect of the cutaneous pain stimulus location same forearm of the pruriceptive stimulus versus the opposite forearm on histaminergic and non-histaminergic itch will be investigated
Detailed Description:
The phenomenon that pain inhibits pain is a well-known mechanism but it is not known if pain is inhibiting itch In this context the aim of this project is to investigate the extent to which thermal or neurogenic short cutaneous pain can affect the itch perception In particular the project aims to understand any differences in itch perception when the painful stimulation is applied on the same forearm versus the opposite forearm The hypothesis is that by applying a painful stimulus at the same time of an itchy stimulus the itch sensitivity will decrease probably due to an inhibitory process conducted by interneurons Bhlbb5 interneuron at central level
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None