Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06182722
Status:
RECRUITING
Last Update Posted:
2024-04-09
First Post:
2023-09-16
Brief Title:
Association of Peripheral Immune Cells With Antidepressant Treatment Response
Sponsor:
Shanghai Mental Health Center
Organization:
Shanghai Mental Health Center
Study Overview
Official Title:
Association of Peripheral Immune Cells With Antidepressant Treatment Response
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this observational study is discovering potential biomarkers to predict antidepressant treatment response in patients with major depressive disorder MDD while comparing the transcriptomic changes between patients with MDD and healthy controls as well as before and after antidepressant treatment
Eligible patients will be assessed at Week 1 Week 2 Week 4 and Week 8 while healthy normal volunteers will only be evaluated at baseline Assessments will include the following an interview about mental and physical health a physical examination including drawing of venous blood samples and several psychiatric rating scales
Eligible patients will be assessed at Week 1 Week 2 Week 4 and Week 8 while healthy normal volunteers will only be evaluated at baseline Assessments will include the following an interview about mental and physical health a physical examination including drawing of venous blood samples and several psychiatric rating scales
Detailed Description:
This study is focusing on evaluating the peripheral immune system of major depressive disorder MDD and the impact of antidepressants treatment Single-cell RNA sequencing and single-cell VDJ sequencing will be performed on peripheral blood mononuclear cells to collect transcriptome information and immune repertoire of peripheral blood in patients with MDD Bulk RNA sequencing and flow cytometry will be used to validate the clinical value of results
This is a biomarker study antidepressants treatment will be carried out according to physicians orders
This is a biomarker study antidepressants treatment will be carried out according to physicians orders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None