Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06180213
Status:
COMPLETED
Last Update Posted:
2023-12-22
First Post:
2023-12-12
Brief Title:
Study of Cerebral Glucose Metabolism in Neurodegenerative Diseases and Head Trauma
Sponsor:
IRCCS San Raffaele
Organization:
IRCCS San Raffaele
Study Overview
Official Title:
Study of Cerebral Glucose Metabolism in Neurodegenerative Diseases and Head Trauma Retrospective Review of an Large Cohort of FDG PET Data
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The reason why each specific degenerative disease is characterized by a different FDG PET pattern is still unclear today There are four main hypotheses proposed to explain this selective vulnerability 1 Nodal stress theory according to which the main nodes of specific brain networks undergo wear and tear 2 trans-neuronal diffusion theory according to which some toxic agentsproteins or altered propagate along network connections through Prion-like mechanisms 3 trophic failure in which the interruption of inter-modal connectivity causes the loss of collateral trophic factors and finally 4 shared vulnerability in which regions also distant from each other are part of a common network which gives a susceptibility uniformly distributed throughout the network
FDG PET provides in-vivo information on the distribution of brain synaptic dysfunction prior to complete neural death and represents the main in vivo biomarker of neural dysfunction associated with different clinical conditions characterized by neurodegeneration phenomena For this reason FDG PET is considered a fundamental approach to shed light on the causes of selective brain vulnerability in various pathological conditions
FDG PET provides in-vivo information on the distribution of brain synaptic dysfunction prior to complete neural death and represents the main in vivo biomarker of neural dysfunction associated with different clinical conditions characterized by neurodegeneration phenomena For this reason FDG PET is considered a fundamental approach to shed light on the causes of selective brain vulnerability in various pathological conditions
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None