Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06181500
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-12-26
First Post:
2023-11-19
Brief Title:
Home-Based Exercise in Primary Progressive Aphasia HEPPA
Sponsor:
Montreal Heart Institute
Organization:
Montreal Heart Institute
Study Overview
Official Title:
Home-Based Exercise in Primary Progressive Aphasia A Pilot Study
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HEPPA
Brief Summary:
This pilot study aims to evaluate the feasibility of a novel home-based multicomponent exercise program in adults clinically diagnosed with Primary Progressive Aphasia
Detailed Description:
Exercise is known to induce changes in brain neuroplasticity in the elderly and is thought to have a protective effect against cognitive decline in patients already suffering from neurodegenerative diseases While the benefits of exercise in the context of mild cognitive impairment and Alzheimers disease have been extensively studied little information is available on the potential benefits of exercise for other atypical neurodegenerative diseases such as primary progressive aphasia PPA A multimodal exercise intervention combination of aerobic and resistance exercises could potentially slow overall cognitive decline in PPA which is characterized by a gradual and isolated dissolution of language function by promoting neurogenesis and neuroplasticity In healthy but inactive older adults exercise increases grey and white matter volume in prefrontal and temporal cortical regions which are specifically impaired in PPA and play an important role in executive functions episodic memory and language skills Exercise could thus modulate certain executive memory and language difficulties generally observed in this clinical population This pilot study aims to evaluate the feasibility of a novel home-based multicomponent exercise program in adults clinically diagnosed with any of the three main variants of PPA semantic non-fluentagrammatic or logopenic The feasibility outcomes will be based on 1 total recruitment and recruitment rate 2 program completion rate 3 compliance and 4 participants ability to train at home with or without a caregivers presence A minimum of 12 participants will be recruited through McGill Universitys Douglas Research Institute and will complete a 6-month home-based multimodal intervention program They will train two to three times a week for 45 minutes and be supervised via videoconference by a kinesiologist from the EPIC Center at the Montreal Heart Institute If desired participants will be accompanied by a partner close friend or relative to facilitate communication especially if they have difficulty understanding instructions or expressing themselves To assess changes in cognition physical and psychological functions participants will complete neuropsychological and functional assessments in-person at baseline These assessments will also be completed at three and six months post-intervention The knowledge gained from this pilot project will be used to assess the feasibility of a full randomized control trial aimed at assessing the effects of multimodal exercise intervention in PPA patients Ultimately an increased understanding of the potential beneficial effects of physical exercise in PPA will allow for more tailored rehabilitative approaches in this clinical population
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None