Ignite Creation Date:
2024-05-06 @ 7:56 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06183658
Status:
RECRUITING
Last Update Posted:
2023-12-27
First Post:
2023-11-22
Brief Title:
Greater-Bay-Area Healthy Aging Brain Study GHABS
Sponsor:
Shenzhen Bay Laboratory
Organization:
Shenzhen Bay Laboratory
Study Overview
Official Title:
Greater-Bay-Area Healthy Aging Brain Study GHABS Biomarker- and Neuroimaging-based Study of the Pathophysiology Characterization and Evolutionary Patterns of Alzheimers Disease
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GHABS
Brief Summary:
The goal of this observational study is to learn about the pathophysiology characterization and evolutionary patterns of Alzheimers disease AD in South China older adults The primary purposes are as follows
1 The prevalence and characteristics of AD in South Chinas aging population
2 Identify novel biomarkers and neuroimaging techniques for early detection and intervention of AD
3 Supporting and fertilizing novel approaches and techniques for early diagnosis and intervention of AD Participants will undergo cognitive assessments blood sample collection and genetic testing Some will undergo CSF collection stool sample collection MRI scanning Aβ PET scanning and tau PET scanning
1 The prevalence and characteristics of AD in South Chinas aging population
2 Identify novel biomarkers and neuroimaging techniques for early detection and intervention of AD
3 Supporting and fertilizing novel approaches and techniques for early diagnosis and intervention of AD Participants will undergo cognitive assessments blood sample collection and genetic testing Some will undergo CSF collection stool sample collection MRI scanning Aβ PET scanning and tau PET scanning
Detailed Description:
The Greater-Bay-Area Healthy Aging Brain Study GHABS a community-based longitudinal cohort study aimed to characterize of Alzheimers disease in South Chinas Aging Population was launched in May 2021 in Shenzhen The GHABS project was approved by the Shenzhen Bay Laboratorys and the collaborated hospitals Ethical Committees Each participant signed the written informed consent of the GHABS project before enrollment The participants who met the inclusion and exclusion requirements were informed about the baseline and follow-up examinations From 2021 to 2026 the GHABS cohort will recruit 1400 individuals aged 55 and older including 1100 CU older adults 200 MCI patients and 100 dementia patients
All the GHABS participants will undergo cognitive assessments genetic screening and blood sample collection Some will have CSF collection stool sample collection MRI scanning Aβ PET scanning and tau PET scanning All baseline examinations will be completed within three months At follow-up clinical assessments and blood sample collection will be conducted annually CSF sample collection MRI scan Aβ PET scan and tau PET scan are evaluated every two years
All the GHABS participants will undergo cognitive assessments genetic screening and blood sample collection Some will have CSF collection stool sample collection MRI scanning Aβ PET scanning and tau PET scanning All baseline examinations will be completed within three months At follow-up clinical assessments and blood sample collection will be conducted annually CSF sample collection MRI scan Aβ PET scan and tau PET scan are evaluated every two years
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None