Ignite Creation Date:
2024-05-06 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06203821
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-10
First Post:
2024-01-02
Brief Title:
Study of Perioperative NP137 and FOLFIRINOX in Resectable Pancreatic Cancer
Sponsor:
Nabeel Badri
Organization:
University of Rochester
Study Overview
Official Title:
A Pilot Study of Perioperative NP137 and FOLFIRINOX in Resectable Pancreatic Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to investigate whether adding the study drug NP137 to a patients treatment regimen before surgery and in combination with chemotherapy afterward can alter the behavior of pancreatic cancer
Detailed Description:
The aim of this study is to evaluate the mechanism of action for a novel anti-Netrin-1 antibody NP137 in patients with pancreatic ductal adenocarcinoma Pre-clinical data indicates that anti-Netrin-1 therapy can preventdelay metastatic progression of disease by inducing cancer cell death through its dependence receptor Unc5b as well as prevent epithelial to mesenchymal transition EMT
This pilot study is designed to provide vital translational scientific information that will inform the design of future clinical trials for NP137 This information includes determining the optimal use of NP137 with cytotoxic as well as the treatment setting of resectable pancreatic cancer
This pilot study is designed to provide vital translational scientific information that will inform the design of future clinical trials for NP137 This information includes determining the optimal use of NP137 with cytotoxic as well as the treatment setting of resectable pancreatic cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None