Ignite Creation Date:
2024-05-06 @ 7:59 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06214442
Status:
RECRUITING
Last Update Posted:
2024-06-10
First Post:
2023-10-24
Brief Title:
Effects of the Menstrual Cycle on Triceps Surae Properties in Women
Sponsor:
Marco Aurélio Vaz PhD
Organization:
Federal University of Rio Grande do Sul
Study Overview
Official Title:
Effects of Menstrual Cycle Phases on Plantar Flexor Neuromechanical Properties and Achilles Tendon Mechanical Properties of Eumenorrheic Women and Hormonal Contraception Users
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The menstrual cycle is an important biological rhythm whereby large cyclic fluctuations in endogenous sex hormones such as estrogen and progesterone are observed which can affect performance Evidence shows that endogenous and exogenous changes in hormone concentrations during the menstrual cycle exert many effects on the nervous and endocrine systems in addition to the connective tissue with consequences for the movement system Pre-clinical studies ie in animal models show an estrogen association with the structural and mechanical properties of tendons and ligaments Several elegant studies performed with female participants have tried to establish the mechanism underlying the effect of estrogen on collagen synthesis and its effects on exercise and functionality Their findings suggest that the tendon properties may be affected when exposed to varying concentrations of estrogen The largest tendon in humans the Achilles tendon has a direct role in functional capacity activities of daily living and locomotion Studies show that the triceps suraes structural and mechanical properties may change throughout the menstrual cycle and that these changes are related to endogenous and exogenous fluctuations in estrogen and progesterone Musculotendinous stiffness which is dependent on the collagen content has been seen to vary considerably over the course of the menstrual cycle In addition it has been reported that females who have been taking the contraceptive pill for at least a year demonstrate lower levels of tendon strain compared to non-pill taking females indicating a possible influence of hormonal state on tendon mechanical properties However the different experimental designs the varied approaches to the evaluations and the lack of studies with high methodological quality limit our understanding of the effects of the different phases of the menstrual cycle on the triceps suraes neuromechanical properties The aim of this observational study will be to investigate whether the morphological mechanical active and passive material and functional properties of the plantar flexor muscles and of the Achilles tendon as well as functional parameters change during voluntary contractions throughout the phases of the menstrual cycle in eumenorrheic women and in users of hormonal contraception Understanding the acute effects of these properties in eumenorrheic women and users of hormonal contraception is essential so that we can adequately plan interventions and prescriptions of physical exercise and rehabilitation aimed for women
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None