Ignite Creation Date:
2024-05-06 @ 8:00 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06213766
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-26
First Post:
2024-01-10
Brief Title:
Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimers Disease
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Joint Analysis of Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimers Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ACTSOMA
Brief Summary:
Spatial navigation is a high-level cognitive function that enables humans to orientate themselves and move around in space by constructing a mental representation of the environment It is particularly interesting because it involves numerous neural networks linked to proprioception and vision for example
Despite the versatility of this cognitive function spatial navigation is little studied clinically although changes in spatial planning and navigation strategies have been associated with many brain disorders including Alzheimers disease Coughlan et al 2018 This may be explained in view of the neuropsychological tests currently in use which do not effectively assess spatial navigation disorders In addition many non-pathological parameters - in particular socio-demographic and lifestyle - Wolbers Hegarty 2010 Coutrot et al 2018 affect spatial navigation performance Separating the pathological component from these non-pathological factors in spatial navigation can be challenging
In this context Sea Hero Quest SHQ has been developed Coutrot et al 2018 Spiers et al 2021 as an international-scale cognitive spatial navigation task that holds great promise for assessing spatial navigation performance during normal and pathological ageing SHQ is a video game that implements classic tasks from the spatial cognition literature and has enabled the trajectories of 4 million players with varied socio-demographic profiles to be collected
In addition to the direct measurement of spatial displacements eye movements measured by eye-tracking provide additional information on the cognitive processes associated with visual attention The analysis of eye movements can provide valuable information about the strategies employed by humans during spatial navigation Zhu et al eLife 2023
While it is well known that normal ageing and pathological ageing eg in the context of Alzheimers disease affect performance in simple spatial navigation or visual attention tasks the neurocognitive mechanisms involved in this deterioration remain poorly understood The investigators hypothesise that the joint analysis of ocular and spatial traces will provide a more detailed understanding of the cognitive strategies deployed during a spatial navigation task and therefore of these underlying mechanisms
The investigators therefore propose to jointly study the association between two complementary cognitive functions spatial navigation and visual attention and their relationship with normal and pathological ageing confirmed Alzheimers disease plasma biomarkers and genetic risk factors for Alzheimers disease The joint analysis of these different signals has never been carried out as part of research into normal ageing and Alzheimers disease
Despite the versatility of this cognitive function spatial navigation is little studied clinically although changes in spatial planning and navigation strategies have been associated with many brain disorders including Alzheimers disease Coughlan et al 2018 This may be explained in view of the neuropsychological tests currently in use which do not effectively assess spatial navigation disorders In addition many non-pathological parameters - in particular socio-demographic and lifestyle - Wolbers Hegarty 2010 Coutrot et al 2018 affect spatial navigation performance Separating the pathological component from these non-pathological factors in spatial navigation can be challenging
In this context Sea Hero Quest SHQ has been developed Coutrot et al 2018 Spiers et al 2021 as an international-scale cognitive spatial navigation task that holds great promise for assessing spatial navigation performance during normal and pathological ageing SHQ is a video game that implements classic tasks from the spatial cognition literature and has enabled the trajectories of 4 million players with varied socio-demographic profiles to be collected
In addition to the direct measurement of spatial displacements eye movements measured by eye-tracking provide additional information on the cognitive processes associated with visual attention The analysis of eye movements can provide valuable information about the strategies employed by humans during spatial navigation Zhu et al eLife 2023
While it is well known that normal ageing and pathological ageing eg in the context of Alzheimers disease affect performance in simple spatial navigation or visual attention tasks the neurocognitive mechanisms involved in this deterioration remain poorly understood The investigators hypothesise that the joint analysis of ocular and spatial traces will provide a more detailed understanding of the cognitive strategies deployed during a spatial navigation task and therefore of these underlying mechanisms
The investigators therefore propose to jointly study the association between two complementary cognitive functions spatial navigation and visual attention and their relationship with normal and pathological ageing confirmed Alzheimers disease plasma biomarkers and genetic risk factors for Alzheimers disease The joint analysis of these different signals has never been carried out as part of research into normal ageing and Alzheimers disease
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None