Ignite Creation Date:
2024-05-06 @ 8:00 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06214676
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-07
First Post:
2024-01-10
Brief Title:
OCTA in Patients With Primary Open-angle Glaucoma
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Detection of Microvascular Changes in Patients With Primary Open Angle Glaucoma by Using Optical Coherence Tomography Angiography
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Is to investigate retinal microvascular changes in primary open angle glaucoma patients using Optical Coherence Tomography Angiography
Detailed Description:
Optical coherence tomography angiography OCT-A is a non-invasive imaging technique developed to visualize vascular networks in the retina and choroid It utilizes low-coherence interferometry to measure changes in backscattered signal to differentiate areas of blood flow from areas of static tissue
OCTA provides both structural and functional ie blood flow information in tandem The corresponding OCT b-scans can be co-registered with the simultaneous OCT angiograms so the operator is able to scroll through the OCT angiogram like a cube scan As a result the precise location of pathology can be viewed on the corresponding OCT b-scans This makes OCTA a better tool when detecting the exact location of a retinal pathology
Glaucoma is the first cause of irreversible blindness and represents approximately 15 of all causes of blindness This makes it a real public health problem In 2020 glaucoma affected about 80 million people worldwide with nearly 75 of open-angle glaucoma Primary open-angle glaucoma POAG is a chronic progressive blinding irreversible optic neuropathy characterized by damage to the optic nerve head and retinal nerve fibers with subsequent visual field defects elevated intraocular pressure IOP is a crucial glaucoma risk factor that causes direct damage to RGCs and the optic nerve Moreover glaucomatous retinsl ganglion cells loss occurs as well in people with normal IOP implying mechanisms behind pressure-mediated damage RGCs death may be due to the reduced blood supply and microvasculature dysfunction may be essential in glaucoma pathogenesis
One hypothesis is that POAG is categorized by impaired chemical endothelial signaling between both a the inner wall Schlemms canal endothelial cells as well as endothelial cells located in the ciliary body and the posterior longitudinal muscle that helps to set outflow resistance and b the ocular vascular endothelial cell and underlying luminal smooth muscle for vessels supplying the retinal ganglion cells RGCs This hypothesis could explain why POAG occurs across a spectrum of IOP but it does not consider the role systemic endothelial cell dysfunction may play in the disease
The non-invasive technique of OCT angiography OCTA can image and quantify both large vessels and the microvasculature of the optic nerve head ONH retina and choroid layers Using the OCTA technique reduced vessel density VD was observed in the ONH peripapillary area and macula predominantly in primary open-angle glaucoma POAG
OCTA provides both structural and functional ie blood flow information in tandem The corresponding OCT b-scans can be co-registered with the simultaneous OCT angiograms so the operator is able to scroll through the OCT angiogram like a cube scan As a result the precise location of pathology can be viewed on the corresponding OCT b-scans This makes OCTA a better tool when detecting the exact location of a retinal pathology
Glaucoma is the first cause of irreversible blindness and represents approximately 15 of all causes of blindness This makes it a real public health problem In 2020 glaucoma affected about 80 million people worldwide with nearly 75 of open-angle glaucoma Primary open-angle glaucoma POAG is a chronic progressive blinding irreversible optic neuropathy characterized by damage to the optic nerve head and retinal nerve fibers with subsequent visual field defects elevated intraocular pressure IOP is a crucial glaucoma risk factor that causes direct damage to RGCs and the optic nerve Moreover glaucomatous retinsl ganglion cells loss occurs as well in people with normal IOP implying mechanisms behind pressure-mediated damage RGCs death may be due to the reduced blood supply and microvasculature dysfunction may be essential in glaucoma pathogenesis
One hypothesis is that POAG is categorized by impaired chemical endothelial signaling between both a the inner wall Schlemms canal endothelial cells as well as endothelial cells located in the ciliary body and the posterior longitudinal muscle that helps to set outflow resistance and b the ocular vascular endothelial cell and underlying luminal smooth muscle for vessels supplying the retinal ganglion cells RGCs This hypothesis could explain why POAG occurs across a spectrum of IOP but it does not consider the role systemic endothelial cell dysfunction may play in the disease
The non-invasive technique of OCT angiography OCTA can image and quantify both large vessels and the microvasculature of the optic nerve head ONH retina and choroid layers Using the OCTA technique reduced vessel density VD was observed in the ONH peripapillary area and macula predominantly in primary open-angle glaucoma POAG
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None