Ignite Creation Date:
2024-05-06 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06229002
Status:
RECRUITING
Last Update Posted:
2024-03-07
First Post:
2023-12-20
Brief Title:
Effect of Transcranial Alternative Current Stimulation at Alpha Frequency α-tACS on Stressed Healthy Subjects
Sponsor:
Hôpital le Vinatier
Organization:
Hôpital le Vinatier
Study Overview
Official Title:
Biological Neuropsychological and Electrophysiological Effect of Transcranial Alternative Current Stimulation at Alpha Frequency α-tACS on Stressed Healthy Subjects
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAF-TAS
Brief Summary:
stress Notably several studies reported that stress could alter impulsivity source monitoring and time perception
Several mechanisms are involved in the response to a stress factor among them the hypothalamic-pituitary-adrenal HPA axis The cortisol reactivity it means the cortisol secretion after the exposure to a standardized stress factor is a reliable tool to assess the function of HPA Cortisol secretion is bidirectionally influenced by the prefrontal cortex PFC which is involved in the expression and regulation of stress as well The asymmetry of the alpha band AFα is a well known electrophysiological parameter to assess the function of PFC More precisely AFα is arising a growing interest as it is believed to be correlated with the cortisol reactivity Modifying this asymmetry could influence the stress response
Transcranial Alternating Current Stimulation tACS consists in delivering a sinusoidal alternating current between two electrodes placed on the scalp at a predefined frequency Previous studious reported that tACS if delivered at the alpha frequency increased the alpha band in the stimulated areas
Several mechanisms are involved in the response to a stress factor among them the hypothalamic-pituitary-adrenal HPA axis The cortisol reactivity it means the cortisol secretion after the exposure to a standardized stress factor is a reliable tool to assess the function of HPA Cortisol secretion is bidirectionally influenced by the prefrontal cortex PFC which is involved in the expression and regulation of stress as well The asymmetry of the alpha band AFα is a well known electrophysiological parameter to assess the function of PFC More precisely AFα is arising a growing interest as it is believed to be correlated with the cortisol reactivity Modifying this asymmetry could influence the stress response
Transcranial Alternating Current Stimulation tACS consists in delivering a sinusoidal alternating current between two electrodes placed on the scalp at a predefined frequency Previous studious reported that tACS if delivered at the alpha frequency increased the alpha band in the stimulated areas
Detailed Description:
The study will focus on the effect of tACS at alpha frequency α-tACS delivered on the dorsolateral prefrontal cortex on the response to a stress factor
In this study while receiving a single α-tACS session the participants will complete a standardized stress test combining cognitive stress mental calculation and physical stress cold pressure the Maastricht Acute Stress Test The main objective aims at assessing the effect of a single session of tACS at alpha frequency delivered on the dorsolateral prefrontal cortex on the cortisol reactivity in healthy stressed subjects In that study the influence of α-tACS on other biological electrophysiological neuropsychological parameters relevant for the stress response will be assessed also
In this study while receiving a single α-tACS session the participants will complete a standardized stress test combining cognitive stress mental calculation and physical stress cold pressure the Maastricht Acute Stress Test The main objective aims at assessing the effect of a single session of tACS at alpha frequency delivered on the dorsolateral prefrontal cortex on the cortisol reactivity in healthy stressed subjects In that study the influence of α-tACS on other biological electrophysiological neuropsychological parameters relevant for the stress response will be assessed also
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None