Ignite Creation Date:
2024-05-06 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06229509
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-29
First Post:
2024-01-09
Brief Title:
Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease COPD Effect of Body Composition
Sponsor:
University Hospital Clermont-Ferrand
Organization:
University Hospital Clermont-Ferrand
Study Overview
Official Title:
Study of Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease COPD Effect of Body Composition
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CYTODINE
Brief Summary:
Dyspnea more commonly known as breathlessness is a symptom found in the majority of patients with chronic obstructive pulmonary disease COPD with a major impact on quality of life and mortality
COPD is a chronic inflammatory disease of the bronchi affecting 8 of the French population more than 3 million people By 2030 it will be the third leading cause of death worldwide Effective management of dyspnea in these patients is a priority
In patients with severe COPD physical exertion increases the workload of breathing leading to dyspnea At the same time the respiratory muscles and fatty cells release cytokines myokines and adipokines - a group of proteins involved in the inflammatory response In addition 15 of COPD patients suffer from sarcopenia loss of muscle mass and strength which increases respiratory effort and dyspnea
Our research project aims to study the effect of dyspnea relief in COPD patients on cytokine myokine and adipokine levels taking into account the presence of sarcopenia Indeed it is possible to alleviate the workload of the respiratory muscles during exercise by means of respiratory assistance
The ultimate goal is a better understanding of dyspnea mechanisms to enable the development of cytokine-targeted therapies and improve quality of life and survival in these patients
COPD is a chronic inflammatory disease of the bronchi affecting 8 of the French population more than 3 million people By 2030 it will be the third leading cause of death worldwide Effective management of dyspnea in these patients is a priority
In patients with severe COPD physical exertion increases the workload of breathing leading to dyspnea At the same time the respiratory muscles and fatty cells release cytokines myokines and adipokines - a group of proteins involved in the inflammatory response In addition 15 of COPD patients suffer from sarcopenia loss of muscle mass and strength which increases respiratory effort and dyspnea
Our research project aims to study the effect of dyspnea relief in COPD patients on cytokine myokine and adipokine levels taking into account the presence of sarcopenia Indeed it is possible to alleviate the workload of the respiratory muscles during exercise by means of respiratory assistance
The ultimate goal is a better understanding of dyspnea mechanisms to enable the development of cytokine-targeted therapies and improve quality of life and survival in these patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None