Ignite Creation Date:
2024-05-06 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06229093
Status:
RECRUITING
Last Update Posted:
2024-01-30
First Post:
2021-12-08
Brief Title:
Multimodal Musical Stimulation for Healthy Neurocognitive Aging
Sponsor:
Northeastern University
Organization:
Northeastern University
Study Overview
Official Title:
Multimodal Musical Stimulation for Healthy Neurocognitive Aging
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Multimodal
Brief Summary:
This is a Stage I randomized sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of brain stimulation with multimodal musical stimulation and control stimulation conditions Results will test the causal role of oscillatory mechanisms of the brain on cognition and will lay the groundwork to the first musical neurophysiologically targeted brain-stimulation device for reversing cognitive decline in aging
Detailed Description:
Music contains amplitude and frequency modulations rapid changes in acoustic signals that convey meaningful information to the listener The human brains ability to receive and interpret meaning from these signals is implemented by networks of neural oscillations firing patterns of groups of neurons that track the music with rhythmic activity Neural oscillations in different frequency bands subserve attention and memory as well as perception and comprehension they develop over the lifespan and are reduced in aging especially in dementia Being able to understand and causally control neural oscillations will have crucial implications for healthy neurocognitive aging Since music naturally stimulates the brain with its rhythmic content over time music may be used as a sustainable naturalistic form of brain stimulation to induce oscillatory in neuronal populations Furthermore by inserting gamma-band energy as sensory stimulation during music listening gamma-band activity may be increased in the brain in a way that is frequency-tuned to the brains intrinsic network dynamics thus replacing the decreased neural oscillations that are reduced in aging and improving memory and cognition in older adults The hypothesis is that gamma-band modulations inserted in lights when coupled with music listening can improve memory in older adults by frequency-tuning to intrinsic individual brain network dynamics Results will test the causal role of oscillatory mechanisms of the brain on cognition If successful this trial will lay the groundwork to the first musical neurophysiologically targeted brain-stimulation device for reversing cognitive decline in aging
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None