Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00000648
Status:
COMPLETED
Last Update Posted:
2021-10-27
First Post:
1999-11-02
Brief Title:
A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To provide information on the response of HIV infected neurosyphilis patients to the currently recommended treatment for neurosyphilis to determine whether possible co-infection with both HIV and syphilis makes more difficult the diagnosis of syphilis to explore the usefulness of an alternative treatment which if effective would permit outpatient treatment for neurosyphilis that until now required prolonged hospitalization
Studies suggest that syphilis treatment failures may be more common in HIV infected patients than in patients without HIV infection and that treatment failures occur due to andor are displayed as central nervous system CNS involvement Very little is known about the best treatment course for neurosyphilis in patients who are also infected with HIV
Studies suggest that syphilis treatment failures may be more common in HIV infected patients than in patients without HIV infection and that treatment failures occur due to andor are displayed as central nervous system CNS involvement Very little is known about the best treatment course for neurosyphilis in patients who are also infected with HIV
Detailed Description:
Studies suggest that syphilis treatment failures may be more common in HIV infected patients than in patients without HIV infection and that treatment failures occur due to andor are displayed as central nervous system CNS involvement Very little is known about the best treatment course for neurosyphilis in patients who are also infected with HIV
HIV infected patients who are presumed to have neurosyphilis or have definitive neurosyphilis are treated for the neurosyphilis with either penicillin G or ceftriaxone Patients are treated for 10 days and followed for 50 weeks after treatment Patients receiving penicillin G are hospitalized while receiving the penicillin Patients receiving ceftriaxone are treated on an inpatient basis for at least the first three days and may then be discharged to receive outpatient treatment During treatment patients are permitted to take antiretroviral drugs or other drugs for opportunistic infections except for drugs that are antisyphilitic Lumbar punctures will be performed
HIV infected patients who are presumed to have neurosyphilis or have definitive neurosyphilis are treated for the neurosyphilis with either penicillin G or ceftriaxone Patients are treated for 10 days and followed for 50 weeks after treatment Patients receiving penicillin G are hospitalized while receiving the penicillin Patients receiving ceftriaxone are treated on an inpatient basis for at least the first three days and may then be discharged to receive outpatient treatment During treatment patients are permitted to take antiretroviral drugs or other drugs for opportunistic infections except for drugs that are antisyphilitic Lumbar punctures will be performed
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: