Ignite Creation Date:
2024-05-06 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06255366
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-15
First Post:
2024-01-23
Brief Title:
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
Sponsor:
Chengdu University of Traditional Chinese Medicine
Organization:
Chengdu University of Traditional Chinese Medicine
Study Overview
Official Title:
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
Detailed Description:
A total of 129 patients diagnosed with lumbar spondylolisthesis and undergoing endoscopic lumbar fusion in our hospital from February 2024 to February 2025 were prospectively enrolled in this trial All subjects who met the inclusion criteria were enrolled in the trial after signing the informed consent form After completing the relevant information registration routine preoperative preparation was performed and relevant baseline data were collected The randomization scheme was completed by specialized statisticians independently and was not affected by the subjective will of the researchers and the subjects According to the random number table method all subjects were equally allocated to group A group B and group C at a ratio of 111 Participants and investigators were blinded to group assignments until the end of the study and were blinded only if a participant developed a serious complication during treatment Blood routine liver function renal function electrolytes coagulation indexes and other hematological tests were routinely performed before operation The volume of blood drawn was about 15ml Experimental group group A Intravenous infusion of caroxime sodium sulfonate and sodium chloride injection 100ml caroxime sodium sulfonate 80mg and sodium chloride 09g Chongqing Dikang was given 5 minutes before operation One hour after operation intravenous infusion of carosene sodium sulfonate injection 100ml carosene sodium sulfonate 80mg and sodium chloride 09g Chongqing Dicang reference to Weiluojing Carosene sodium sulfonate sodium chloride injection 100ml 80mg 09g Usage and dosage intravenous infusion of 80mg each time approval number Chinese Medicine approval number H20052472 Experimental group group B Intravenous infusion of desmopressin injection 15ug Shenzhen Hanyu 09 sodium chloride injection 100ml 5 minutes before surgery intravenous infusion of desmopressin injection 15ug Shenzhen Hanyu 09 sodium chloride injection 100ml 1 hour after surgery according to the instructions of desmopressin injection Hangu usage and dosage 1 Control of bleeding or prevention of bleeding before operation according to the dose of 03ugkg body weight diluted to 50-100ml with normal saline intravenous infusion within 15-30min approval number H20064093 In control group group C 100ml 09 sodium chloride solution was intravenously infused 5 minutes before surgery and again 1 hour after surgery Intraoperative Gertzbein-Sload GS score was used to score the clarity of the intraoperative visual field under the microscope During the operation the operation time and the total amount of perfusate were recorded and the red blood cell count was measured by taking the perfusate from the drainage bottle The blood routine erythrocyte sedimentation rate CRP and IL-6 were rechecked at 3 days and the amount of blood drawn was about 10ml each time The total blood loss intraoperative blood loss and hidden blood loss of the patients were recorded and the VAS scores at 1 day 2 days and 3 days after operation were recorded To evaluate the effect of intravenous administration of carosodiumsulfonate and desmopressin on the clarity of visual field under endoscope perioperative blood loss and postoperative inflammatory indicators in endoscopic lumbar fusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None