Ignite Creation Date:
2024-05-06 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06256809
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-21
First Post:
2024-02-01
Brief Title:
Analyzing Handprint Patterns to Predict Oral Cancer Risks A Comparative Study
Sponsor:
King Khalid University
Organization:
King Khalid University
Study Overview
Official Title:
Qualitative and Quantitative Analysis of Finger and Palmer Dermatoglyphics Traits in Potentially Malignant and Malignant Lesions of the Oral Cavity for Genetic Predilection A Case-Control Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
QQA-FPD-PMML
Brief Summary:
Aims To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES 1 To record and study the palmar and fingerprint patterns in patients with oral premalignant and malignant lesions 2 To assess the variations in patterns of dermatoglyphic features between cases and controls and to observe the significant result
3 To evaluate which dermatoglyphic pattern is predominant among patients with premalignant and malignant lesions
Materials and METHODS Fingerprints and palm prints were studied in 160 patients who were randomly divided into four groups A 40 patients with a history of areca nut tobacco intake with the occurrence of the premalignant lesion B 40 patients with a history of areca nut tobacco intake with the occurrence of Oral Squamous Cell Carcinoma C As healthy controls 40 patients with tobaccoareca nut chewing habits without any evidence of oral lesions D 40 patients without any habit and without any oral lesions Dermatoglyphic patterns were recorded and analyzed in the four groups using the standard ink method
3 To evaluate which dermatoglyphic pattern is predominant among patients with premalignant and malignant lesions
Materials and METHODS Fingerprints and palm prints were studied in 160 patients who were randomly divided into four groups A 40 patients with a history of areca nut tobacco intake with the occurrence of the premalignant lesion B 40 patients with a history of areca nut tobacco intake with the occurrence of Oral Squamous Cell Carcinoma C As healthy controls 40 patients with tobaccoareca nut chewing habits without any evidence of oral lesions D 40 patients without any habit and without any oral lesions Dermatoglyphic patterns were recorded and analyzed in the four groups using the standard ink method
Detailed Description:
The skin is the protective layer covering the entire human body which acts as a barrier against various pathogens and also acts as a thermoregulatory organ Skin is covered with hair follicles and sebaceous glands except in the palmar aspect of hands and the plantar aspect of soles Both regions of the human body are devoid of hair and sebaceous glands but these parts have increased nerve supply due to the presence of more sensory receptors
A unique ridge pattern is present on the palmar aspect of hands and the plantar aspect of soles called Epidermal Ridges ER These ridges are uniquedifferent for every individual Primarily these ridges help in gripping the surface After conception this pattern starts to develop from the 7th to 21st week of intra-gestation life Creating a certain manner of sweat gland pore arrangement around the Papilla Conical eminence leads to the formation of epidermal ridges and is completed by 52 days of the gestation period
Various factors influenced the development of these pattern formations which include genetic and environmental factors Abnormal configuration of dermal patterns is influenced by both genetic and environmental factors causing disturbance during the intrauterine gestation period of the fetus One classic example of abnormal dermal patterns is associated with Down syndrome where there will be an alteration in the Ridge pattern due to retardation affecting the growth of different parts of bodies and ER
The study of this variation of ER and fingertips of palm and sole is known as Dermatoglyphics
In Greek Derma means skin and Glyphic means curved The initiation of Dermatoglyphic was done by Sir Frank Galton and he classified it into three patterns Loops arches and whorls Harold Clements conducted the first study on genetic abnormality with Dermatoglyphics patterns in Down syndromes The Father of dermatoglyphics is Cummins J CA Mayer in 1788 concludes in his study on fingerprint analysis that dermatoglyphics pattern cannot be duplicated in two individuals In 1858 Sir William Herschel British Chief Administrator of Officer in West Bengal was the first to use dermatoglyphics for personal identification which was used for criminology Patterns of Dermatoglyphics can influence the genetic makeup of an individual which can act as a guide for genetic diseases such as Down syndrome Klinefelters syndrome cancer Alzheimers ovarian cancer and schizophrenia
Fingerprints are different in each individual these are inherited and permanent to one particular individual and do not repeat or change among parents or siblings not even in the monozygotic twins Unless in case of severe burns cuts and bruises due to this The preliminary feature of these fingerprints they can be used as evidence for the identification of a person in the forensic department and can be used as a tool in many genetic abnormality studies
Oral Leukoplakia OL and oral submucous fibrosis OSF are more common premalignant lesions with high risk of malignant transformation rates of 06 to 20 and 15 to 15 respectively
Both lesions are majorly caused due to tobacco usage in different forms and associated with various features affecting oral mucosa like ulceration xerostomia burning sensation and alteration in collagen deposition These pre-malignant lesions of the oral cavity commonly lead to the formation of Oral squamous cell carcinoma OSCC due to alterations in the function of genes
Human genes regulate Cell signaling and tumor suppression which contributes to a decrease in cancer cell production The two main factors which influence most diseases are genetic and epigenetic Development of oral or head and neck squamous cell carcinoma HNSCC is influenced by both these factors Population-based studies to determine the genetic or familial disposition to oral cancers are limited by coexisting risk factors like smoking and alcohol It is also believed that certain individuals inherit the susceptibility of inability to metabolize carcinogens or procarcinogens andor an impaired ability to repair DNA damage Oncogenes are altered growth-promoting regulatory genes that govern the cells signal transduction pathways and mutation of these genes leads to either overproduction or increased function of the excitatory proteins Several oncogenes have been implicated in oral carcinogenesis Aberrant expression of the proto-oncogene epidermal growth factor receptor EGFRc-erb 1 members of the ras gene family c-myc int-2 hst-1 PRAD-1 and bcl-1 is believed to contribute towards cancer development Hence the study of these genetic functions and the abnormality of genes has a potential role in diagnosing the malignancy earlier However this procedure required for the assessment of genes is expensive and complex Therefore assessing dermatoglyphics traits can be a simple cost-effective non-invasive procedure along with clinical features for the early diagnosis of cancer OSCC and pre-malignant lesions
This study is conducted with the following objectives and aims
1 To record and study the palmar and fingerprint patterns in patients with oral premalignant and malignant lesions
2 To assess the variations in patterns of dermatoglyphic features between cases and controls and to observe the significant result
3 To evaluate which dermatoglyphic pattern is predominant among patients with premalignant and malignant lesions
4 To assess the usefulness of this technique in acting as a predictor of oral squamous cell carcinoma the efficacy of this technique as a non-invasive diagnostic tool in the identification of oral squamous cell carcinoma patients and also to identify persons at risk of oral squamous cell carcinoma
This study is assessed based on the following parameters 1 Qualitative parameters a Whorls b Loops c Arches 2 Quantitative parameters a Total finger ridge count TFRC b angle of the palm at angles
A unique ridge pattern is present on the palmar aspect of hands and the plantar aspect of soles called Epidermal Ridges ER These ridges are uniquedifferent for every individual Primarily these ridges help in gripping the surface After conception this pattern starts to develop from the 7th to 21st week of intra-gestation life Creating a certain manner of sweat gland pore arrangement around the Papilla Conical eminence leads to the formation of epidermal ridges and is completed by 52 days of the gestation period
Various factors influenced the development of these pattern formations which include genetic and environmental factors Abnormal configuration of dermal patterns is influenced by both genetic and environmental factors causing disturbance during the intrauterine gestation period of the fetus One classic example of abnormal dermal patterns is associated with Down syndrome where there will be an alteration in the Ridge pattern due to retardation affecting the growth of different parts of bodies and ER
The study of this variation of ER and fingertips of palm and sole is known as Dermatoglyphics
In Greek Derma means skin and Glyphic means curved The initiation of Dermatoglyphic was done by Sir Frank Galton and he classified it into three patterns Loops arches and whorls Harold Clements conducted the first study on genetic abnormality with Dermatoglyphics patterns in Down syndromes The Father of dermatoglyphics is Cummins J CA Mayer in 1788 concludes in his study on fingerprint analysis that dermatoglyphics pattern cannot be duplicated in two individuals In 1858 Sir William Herschel British Chief Administrator of Officer in West Bengal was the first to use dermatoglyphics for personal identification which was used for criminology Patterns of Dermatoglyphics can influence the genetic makeup of an individual which can act as a guide for genetic diseases such as Down syndrome Klinefelters syndrome cancer Alzheimers ovarian cancer and schizophrenia
Fingerprints are different in each individual these are inherited and permanent to one particular individual and do not repeat or change among parents or siblings not even in the monozygotic twins Unless in case of severe burns cuts and bruises due to this The preliminary feature of these fingerprints they can be used as evidence for the identification of a person in the forensic department and can be used as a tool in many genetic abnormality studies
Oral Leukoplakia OL and oral submucous fibrosis OSF are more common premalignant lesions with high risk of malignant transformation rates of 06 to 20 and 15 to 15 respectively
Both lesions are majorly caused due to tobacco usage in different forms and associated with various features affecting oral mucosa like ulceration xerostomia burning sensation and alteration in collagen deposition These pre-malignant lesions of the oral cavity commonly lead to the formation of Oral squamous cell carcinoma OSCC due to alterations in the function of genes
Human genes regulate Cell signaling and tumor suppression which contributes to a decrease in cancer cell production The two main factors which influence most diseases are genetic and epigenetic Development of oral or head and neck squamous cell carcinoma HNSCC is influenced by both these factors Population-based studies to determine the genetic or familial disposition to oral cancers are limited by coexisting risk factors like smoking and alcohol It is also believed that certain individuals inherit the susceptibility of inability to metabolize carcinogens or procarcinogens andor an impaired ability to repair DNA damage Oncogenes are altered growth-promoting regulatory genes that govern the cells signal transduction pathways and mutation of these genes leads to either overproduction or increased function of the excitatory proteins Several oncogenes have been implicated in oral carcinogenesis Aberrant expression of the proto-oncogene epidermal growth factor receptor EGFRc-erb 1 members of the ras gene family c-myc int-2 hst-1 PRAD-1 and bcl-1 is believed to contribute towards cancer development Hence the study of these genetic functions and the abnormality of genes has a potential role in diagnosing the malignancy earlier However this procedure required for the assessment of genes is expensive and complex Therefore assessing dermatoglyphics traits can be a simple cost-effective non-invasive procedure along with clinical features for the early diagnosis of cancer OSCC and pre-malignant lesions
This study is conducted with the following objectives and aims
1 To record and study the palmar and fingerprint patterns in patients with oral premalignant and malignant lesions
2 To assess the variations in patterns of dermatoglyphic features between cases and controls and to observe the significant result
3 To evaluate which dermatoglyphic pattern is predominant among patients with premalignant and malignant lesions
4 To assess the usefulness of this technique in acting as a predictor of oral squamous cell carcinoma the efficacy of this technique as a non-invasive diagnostic tool in the identification of oral squamous cell carcinoma patients and also to identify persons at risk of oral squamous cell carcinoma
This study is assessed based on the following parameters 1 Qualitative parameters a Whorls b Loops c Arches 2 Quantitative parameters a Total finger ridge count TFRC b angle of the palm at angles
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| RGP134744 | OTHER_GRANT | King Khalid University | None |