Ignite Creation Date:
2024-05-06 @ 8:07 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06266741
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-02-20
First Post:
2023-10-25
Brief Title:
The Predictive Value of Lubricin in Patients With Infective Endocarditis
Sponsor:
Aydin Adnan Menderes University
Organization:
Aydin Adnan Menderes University
Study Overview
Official Title:
The Predictive Value of Lubricin in Patients With Infective Endocarditis
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients
Detailed Description:
Infective endocarditis is a challenging disease with a wide range of clinical presentations making it difficult to diagnose Diagnosis primarily relies on clinical suspicion based on symptoms Blood cultures or other microbial tests confirming the presence of infection and echocardiography are supportive diagnostic tools Another marker that may become valuable in the near future for diagnosing infective endocarditis is Lubricin Lubricin a glycoprotein expressed by the PRG4 gene has been found to have significantly elevated levels in the plasma of animals with damaged or infected heart valves compared to healthy animals Furthermore plasma lubricin levels can potentially serve as a biomarker in situations like endocardial injury and infection Lubricin and Procalcitonin will be studied from the blood samples routinely collected During this academic study procalcitonin and lubricin values will be measured by investigators Thus the sensitivity and specificity of the Lubricin parameter in patients with infective endocarditis will be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None