Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06264336
Status:
RECRUITING
Last Update Posted:
2024-05-07
First Post:
2024-02-01
Brief Title:
Effects of High-intensity Gait Training on Fatigue Gait and Neuroplasticity in People With Multiple Sclerosis
Sponsor:
University of Illinois at Chicago
Organization:
University of Illinois at Chicago
Study Overview
Official Title:
Effects of High-intensity Gait Training on Fatigue Gait and Neuroplasticity in People With Multiple Sclerosis
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Nearly 1 million individuals in the United States have multiple sclerosis which causes fatigue and problems with walking Fatigue and walking problems are poorly treated but exercise training particularly high-intensity walking exercise may help This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis which could improve quality of life and reduce economic burden
Detailed Description:
Multiple sclerosis MS is an immune-mediated neurodegenerative disease of the central nervous system with a prevalence of nearly 1 million adults in the US The pathophysiology of this disease results in two of the hallmark features of MS namely symptomatic fatigue and walking impairment These two features of MS are inter-related as symptomatic fatigue is often a driver of declines in walking and worsening of disability over time and both compromise quality of life and independence To date fatigue and walking impairment are poorly managed through conventional disease modifying medications or rehabilitation therapy in MS
One approach for improving fatigue and walking in MS is an appropriate dose of exercise training Current recommendations of 30 minday 2 daysweek of low to moderate exercise training can improve symptomatic fatigue aerobic capacity strength and walking endurance and other symptoms in people with MS This prescription is often delivered using moderate-intensity continuous training MCT walking However improvements in fatigue and walking outcomes have been small suggesting that MCT may not be the optimal approach In people with stroke high intensity interval-based walking exercise has provided a greater stimulus than MCT for improving outcomes but this approach has not been researched in MS
There are a few field-wide limitations of research on exercise training fatigue and walking outcomes in MS Often researchers have a enrolled people with MS regardless of symptomatic fatigue andor walking dysfunction and this yields floor effects in outcomes and prevents conclusions on exercise as a treatment approach b included people with mild disability but not moderate or severe disability and c applied exercise modalities not based on the principle of specificity ie using walking training to improve fatigue and walking impairment This project overcomes these field-wide limitations and compares effects of moderate and high intensity treadmill training on symptomatic fatigue and walking in people with MS with elevated fatigue and walking dysfunction
One approach for improving fatigue and walking in MS is an appropriate dose of exercise training Current recommendations of 30 minday 2 daysweek of low to moderate exercise training can improve symptomatic fatigue aerobic capacity strength and walking endurance and other symptoms in people with MS This prescription is often delivered using moderate-intensity continuous training MCT walking However improvements in fatigue and walking outcomes have been small suggesting that MCT may not be the optimal approach In people with stroke high intensity interval-based walking exercise has provided a greater stimulus than MCT for improving outcomes but this approach has not been researched in MS
There are a few field-wide limitations of research on exercise training fatigue and walking outcomes in MS Often researchers have a enrolled people with MS regardless of symptomatic fatigue andor walking dysfunction and this yields floor effects in outcomes and prevents conclusions on exercise as a treatment approach b included people with mild disability but not moderate or severe disability and c applied exercise modalities not based on the principle of specificity ie using walking training to improve fatigue and walking impairment This project overcomes these field-wide limitations and compares effects of moderate and high intensity treadmill training on symptomatic fatigue and walking in people with MS with elevated fatigue and walking dysfunction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None