Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06264206
Status:
COMPLETED
Last Update Posted:
2024-02-16
First Post:
2024-02-12
Brief Title:
Effect of Immunomodulatory Treatment on IVF in Vitro Fertilization Outcomes in Patients With KIR AA Genotype
Sponsor:
Calla IVF Center
Organization:
Calla IVF Center
Study Overview
Official Title:
Effect of Immunomodulatory Treatment on IVF Outcomes in Patients With KIRR AA Genotype a Retrospective Cohort Study With Implications for Personalized Fertility Strategies
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study is to investigate the immune cause of recurrent implantation failure RIF and the role of immunomodulatory treatment in IVF in vitro fertilization patients that have a KIR AA genotype We compared pregnancy rates in Group KIR AA without immunomodulatory treatment and pregnancy rates in Group KIR AA with immunomodulatory treatment
Detailed Description:
The investigators included patients that underwent an IVF in vitro fertilization procedure in CALLA IVF Clinic Oradea - Romania between 01 January 2022 and 31 December 2023
Recurrent implantation failure RIF impacts 10 of couples undergoing in vitro fertilization IVF prompting the exploration of tailored treatments to address underlying causes and enhance implantation rates Among these causes maternal immune tolerance toward embryos has garnered significant attention in RIF research with Killer-cell immunoglobulin-like receptors KIRs on natural killer NK cells emerging as key players in maternal-fetal immune interactions The investigation into KIR alleles KIR AA in RIF is rooted in the theory that specific KIR-HLA-C combinations may contribute to implantation failures Recent studies suggest that KIR genotyping could serve as a predictive tool for RIF potentially enabling personalized approaches in assisted reproductive technology such as immunomodulatory treatments and tailored embryo transfers
All couples underwent IVF ovarian stimulation with various factors documented including age type of infertility number of oocytes retrieved number of embryos produced pregnancy rate
A total of 65 patients were enrolled in this study with 24 patients included in group A this is the group with KIR AA and 41 patients included in the group B meaning the group with the KIR Bx Inclusion criteria patients with an infertility diagnosis having an IVF procedure with at least two top-quality embryo to transfer according to Gardners criteria that sign the accord to be enrolled in this study with a negative test for chronic endometritis and normal hysteroscopic findings also patients that have an history of recurrent pregnancy loss and have an IVF indication will be tested in the first round
Exclusion criteria absence of signed consent refusal of hysteroscopy uterine abnormalities thin endometrium endometrial polyps pelvic cancer acute inflammatory disease Asherman syndrome chronic endometritis oocyte or spermatozoa donor
The KIR AA group experienced improved pregnancy outcomes compared to those in the same cohort who did not undergo prior immunomodulatory treatment
Recurrent implantation failure RIF impacts 10 of couples undergoing in vitro fertilization IVF prompting the exploration of tailored treatments to address underlying causes and enhance implantation rates Among these causes maternal immune tolerance toward embryos has garnered significant attention in RIF research with Killer-cell immunoglobulin-like receptors KIRs on natural killer NK cells emerging as key players in maternal-fetal immune interactions The investigation into KIR alleles KIR AA in RIF is rooted in the theory that specific KIR-HLA-C combinations may contribute to implantation failures Recent studies suggest that KIR genotyping could serve as a predictive tool for RIF potentially enabling personalized approaches in assisted reproductive technology such as immunomodulatory treatments and tailored embryo transfers
All couples underwent IVF ovarian stimulation with various factors documented including age type of infertility number of oocytes retrieved number of embryos produced pregnancy rate
A total of 65 patients were enrolled in this study with 24 patients included in group A this is the group with KIR AA and 41 patients included in the group B meaning the group with the KIR Bx Inclusion criteria patients with an infertility diagnosis having an IVF procedure with at least two top-quality embryo to transfer according to Gardners criteria that sign the accord to be enrolled in this study with a negative test for chronic endometritis and normal hysteroscopic findings also patients that have an history of recurrent pregnancy loss and have an IVF indication will be tested in the first round
Exclusion criteria absence of signed consent refusal of hysteroscopy uterine abnormalities thin endometrium endometrial polyps pelvic cancer acute inflammatory disease Asherman syndrome chronic endometritis oocyte or spermatozoa donor
The KIR AA group experienced improved pregnancy outcomes compared to those in the same cohort who did not undergo prior immunomodulatory treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None