Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06265948
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-20
First Post:
2024-02-11
Brief Title:
Comparsion Between Intravenous Infusion of Ketofol and Inhalational Anasthetics in Abdominal Cancer Surgeries for Post Operative Analgesia
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Comparsion Between Intravenous Infusion of Ketofol and Inhalational Anasthetics in Abdominal Cancer Surgeries for Post Operative Analgesia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
post operative pain between intravenous infusion ketofol and standard inhalational general anesthesia in abdominal cancer surgeries
Detailed Description:
ketofol which is a combination of ketamine and propofol has been increasingly used because the advantages and disadvantages of propofol and ketamine complement each other and increase their effectiveness Recently the use of a combination of ketamine and propofol ketofol as a sedative has been attracting attention in various clinical fields Theoretically the combination of ketamine and propofol can reduce the dose of each drug and compensate for the disadvantages of the other through the antagonistic characteristics of both drugs resulting in beneficial results for successful sedation
Most of the time propofol and ketamine have been used as an induction agent in adult surgical patients but propofol may cause cardiorespiratory depression while ketamine increases heart rate and arterial blood pressure On the other hand the clinical effects of propofol and ketamine seem to be complementary Ketofol is most commonly used for procedural sedation hence exploring its effectiveness for induction will be paramount for the clinical care of surgical patients Inhalation anesthetics nitrous oxide halothane isoflurane desflurane sevoflurane most commonly used agents in practice today are used for induction and maintenance of general anesthesia in the operating room The volatile anesthetics halothane isoflurane desflurane and sevoflurane are liquids at room temperature and require the use of vaporizers for inhalational administration Nitrous Oxide is already under normal conditions of temperature and pressure All inhalational anesthetics provide amnesia and immobility except for nitrous oxide which also provides analgesia Inhaled anesthetics are commonly used in combination with IV anesthetic agents These agents have FDA approval for use as a general anesthetic and sedation agent in the operating room Inhaled anesthetic agents have also had use in the intensive care unit but this is not an FDA-approved indication The primary applications of inhaled anesthetic agents in the ICU are sedation refractory bronchospasm and control of status epilepticus unresponsive to anticonvulsant medications
Most of the time propofol and ketamine have been used as an induction agent in adult surgical patients but propofol may cause cardiorespiratory depression while ketamine increases heart rate and arterial blood pressure On the other hand the clinical effects of propofol and ketamine seem to be complementary Ketofol is most commonly used for procedural sedation hence exploring its effectiveness for induction will be paramount for the clinical care of surgical patients Inhalation anesthetics nitrous oxide halothane isoflurane desflurane sevoflurane most commonly used agents in practice today are used for induction and maintenance of general anesthesia in the operating room The volatile anesthetics halothane isoflurane desflurane and sevoflurane are liquids at room temperature and require the use of vaporizers for inhalational administration Nitrous Oxide is already under normal conditions of temperature and pressure All inhalational anesthetics provide amnesia and immobility except for nitrous oxide which also provides analgesia Inhaled anesthetics are commonly used in combination with IV anesthetic agents These agents have FDA approval for use as a general anesthetic and sedation agent in the operating room Inhaled anesthetic agents have also had use in the intensive care unit but this is not an FDA-approved indication The primary applications of inhaled anesthetic agents in the ICU are sedation refractory bronchospasm and control of status epilepticus unresponsive to anticonvulsant medications
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None