Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06261073
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-15
First Post:
2024-02-08
Brief Title:
Evaluation of Serum and Tissue Cathepsin L in Non-segmental Vitiligo Patients
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Evaluation of Serum and Tissue Cathepsin L in Non-segmental Vitiligo Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Vitiligo is an autoimmune disease of the skin that targets pigment producing melanocytes and results in patches of depigmentation that are visible as white spots Frisoli et al 2020 Vitiligo is a relatively common acquired pigmentation disorder that can cause significant psychological stress Leung AKC et al 2021 The disease affects both genders equally it can appear at any age and the average age of onset is somewhat variable in different geographic Majumder et al 1993 with an estimated prevalence of 05-2 of the population in both adults and children worldwide Krüger et al 2012
Vitiligo results in white macules and patches on the body Initial lesions occur most frequently on the hands forearms feet and face favoring a periocular or perioral distribution Ahmed jan N et al 2023 Vitiligo lesions are classified into 2 major categories segmental vitiligo SV and non-segmental vitiligo NSV Relke et al 2019 Segmental vitiligo is characterized by its early onset rapid stabilization and unilateral distribution Van Geel et al 2017 Non-segmental vitiligo comprises of generalized vitiligo vulgaris acrofacial mucosal multifocal and universal vitiligo Kovacevic et al 2016 Non-segmental vitiligo NSV is the most common form of vitiligo Benzekri et al 2013 Multiple mechanisms are involved in melanocyte disappearance namely genetic predisposition environmental triggers metabolic abnormalities impaired renewal and altered inflammatory and immune responses Boniface K et al 2018
The results of some studies indicate a frequent association of vitiligo with autoimmune diseases A number of studies have established a higher prevalence of autoimmune endocrine diseases in women as well as in non-segmental vitiligo patients and in cases of family history of vitiligo andor other autoimmune diseases In addition it was shown that the prevalence of endocrine diseases increases with increasing area of depigmentation Troshina EA et al 2020 Autoimmunity in vitiligo is driven by the IFN-γ-CXCL10 cytokine signaling pathway Activated melanocyte-specific CD8 T cells secrete IFN-γ which signals through the IFN-γ receptor IFN-γR to activate JAK12 and STAT1 This induces the production of CXCL9 and CXCL10 which signal through their receptor CXCR3 to recruit more auto-reactive T cells to the epidermis resulting in widespread melanocyte destruction Harris JE et al 2017
The lysosomal cysteine proteinases of the papain family are involved in lysosomal bulk proteolysis major histocompatibility complex class II-mediated antigen presentation pro-hormone processing and extracellular matrix remodeling
Vitiligo results in white macules and patches on the body Initial lesions occur most frequently on the hands forearms feet and face favoring a periocular or perioral distribution Ahmed jan N et al 2023 Vitiligo lesions are classified into 2 major categories segmental vitiligo SV and non-segmental vitiligo NSV Relke et al 2019 Segmental vitiligo is characterized by its early onset rapid stabilization and unilateral distribution Van Geel et al 2017 Non-segmental vitiligo comprises of generalized vitiligo vulgaris acrofacial mucosal multifocal and universal vitiligo Kovacevic et al 2016 Non-segmental vitiligo NSV is the most common form of vitiligo Benzekri et al 2013 Multiple mechanisms are involved in melanocyte disappearance namely genetic predisposition environmental triggers metabolic abnormalities impaired renewal and altered inflammatory and immune responses Boniface K et al 2018
The results of some studies indicate a frequent association of vitiligo with autoimmune diseases A number of studies have established a higher prevalence of autoimmune endocrine diseases in women as well as in non-segmental vitiligo patients and in cases of family history of vitiligo andor other autoimmune diseases In addition it was shown that the prevalence of endocrine diseases increases with increasing area of depigmentation Troshina EA et al 2020 Autoimmunity in vitiligo is driven by the IFN-γ-CXCL10 cytokine signaling pathway Activated melanocyte-specific CD8 T cells secrete IFN-γ which signals through the IFN-γ receptor IFN-γR to activate JAK12 and STAT1 This induces the production of CXCL9 and CXCL10 which signal through their receptor CXCR3 to recruit more auto-reactive T cells to the epidermis resulting in widespread melanocyte destruction Harris JE et al 2017
The lysosomal cysteine proteinases of the papain family are involved in lysosomal bulk proteolysis major histocompatibility complex class II-mediated antigen presentation pro-hormone processing and extracellular matrix remodeling
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None