Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06265870
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2024-02-10
Brief Title:
Specific Versus Empirical Anthelminthic Treatment in Eosinophilia
Sponsor:
Prince of Songkla University
Organization:
Prince of Songkla University
Study Overview
Official Title:
Comparison of Outcome Between Specific Anthelminthic Treatment According to Test Results and Empirical Anthelminthic Treatment in Eosinophilic Patient
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Eosinophilia
Brief Summary:
There are a few guidelines recommend about management of eosinophilia worldwide most of guielines recommend a thorough history-taking and physical examination Subsequently investigations are requested based on suspected causes In cases where parasite infection is suspected particularly in developing countries stool microscopy and serology are recommended However limitations such as low sensitivity of stool microscopy the inconvenience of collecting multiple stool samples and the high cost and unavailability of serology may arise Consequently some physicians opt for empiric anthelminthic regimens in managing eosinophilic patients even without stool tests or if stool test results are normal If subsequent complete blood count CBC results show a recovery of absolute eosinophil count it is assumed that eosinophilia was caused by a parasite infection While some studies demonstrate the efficacy and simplicity of this approach there is a risk of overestimating parasite infection in eosinophilic patients potential adverse drug reactions from unnecessary anthelminthic treatment and the possibility of drug resistance due to inappropriate dosing To address this gap no study has yet compared the efficacy between specific anthelminthic treatment based on test results and empirical anthelminthic treatment in eosinophilic patients Therefore the investigators are conducting this study
Detailed Description:
Eosinophilia is defined as an absolute eosinophil count exceeding 500 cells per microliter calculated by multiplying the white blood cell count by the percentage of eosinophils
Cause of eosinophilia vary from mild to life-threatening disease Prevalence of each cause of eosinophilia vary on study population the most common etiology in developing country is parasite infection
Stool microscopy can be conducted using various methods The Kato-Katz technique recommended by the WHO exhibits a sensitivity of only 524 percent 95CI 476 - 571 percent More sensitive methods for parasite detection in stool such as stool culture or PCR are not readily available and can be costly In the intervention group of this study the investigators employed three different parasite detection methods stool microscopy stool culture and PCR to enhance sensitivity in detecting parasites
Cause of eosinophilia vary from mild to life-threatening disease Prevalence of each cause of eosinophilia vary on study population the most common etiology in developing country is parasite infection
Stool microscopy can be conducted using various methods The Kato-Katz technique recommended by the WHO exhibits a sensitivity of only 524 percent 95CI 476 - 571 percent More sensitive methods for parasite detection in stool such as stool culture or PCR are not readily available and can be costly In the intervention group of this study the investigators employed three different parasite detection methods stool microscopy stool culture and PCR to enhance sensitivity in detecting parasites
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None