Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06272461
Status:
RECRUITING
Last Update Posted:
2024-04-16
First Post:
2024-01-19
Brief Title:
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Sponsor:
University Tunis El Manar
Organization:
University Tunis El Manar
Study Overview
Official Title:
The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer A Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients undergoing open colorectal surgery were randomly divided into two groups Intravenous Lidocaine IV-Lido vs Intravenous Ketamine IV-Keta
For the IV-Lido group patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours
For the IV-Keta goup patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours
Plasma concentrations of Interleukin-6IL-6 were measured preoperatively before anesthetic induction and at twenty-four hour post operatively
For the IV-Lido group patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours
For the IV-Keta goup patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours
Plasma concentrations of Interleukin-6IL-6 were measured preoperatively before anesthetic induction and at twenty-four hour post operatively
Detailed Description:
Patients undergoing open colorectal surgery with tumor resection were randomised prospectively into two groups Intravenous Lidocaine IV-Lido vs Intravenous Ketamine IV-Keta
For the IV-Lido group n25 patients received a loading dose of 15 mgkg of Lidocaine than a continuous infusion of 15 mgkgh over twenty-four hours
For the IV-Keta goupn25 patients received a loading dose of 015mgkg of Ketamine than a continuous injection of 015 mgkgh of Ketamine over twenty-four hours
For both groups plasma concentrations of Interleukin-6IL-6 were measured preoperatively before anesthetic induction and at twenty-four hour post operatively Plasma IL-6 concentrations at each point were compared between the groups
For the IV-Lido group n25 patients received a loading dose of 15 mgkg of Lidocaine than a continuous infusion of 15 mgkgh over twenty-four hours
For the IV-Keta goupn25 patients received a loading dose of 015mgkg of Ketamine than a continuous injection of 015 mgkgh of Ketamine over twenty-four hours
For both groups plasma concentrations of Interleukin-6IL-6 were measured preoperatively before anesthetic induction and at twenty-four hour post operatively Plasma IL-6 concentrations at each point were compared between the groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None