Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06272071
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-04
First Post:
2024-02-14
Brief Title:
A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis Liver Failure Complicated With Infection
Sponsor:
Zhejiang University
Organization:
Zhejiang University
Study Overview
Official Title:
A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis Liver Failure Complicated With Infection
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection draw the pedigree of pathogenic microorganisms and evaluate its influence on disease outcome in patients with severe hepatitis liver failure The main questions it aims to answer are
Mapping of infectious agents in patients with severe hepatitis liver failure
Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function
Mapping of infectious agents in patients with severe hepatitis liver failure
Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function
Detailed Description:
Liver failure is a clinical syndrome caused by a large number of necrotic hepatocytes leading to severe liver function damage with jaundice coagulation dysfunction and hepatic encephalopathy as the main manifestations which can be caused by a variety of reasons and the liver failure caused by Hepatitis B Virus HBV is the first one in our country which accounts for about 80 of the cases Through the Eleventh Five-Year Plan to Thirteenth Five-Year Plan national scientific and technological major special projects the death rate of patients with early and middle stage of severe hepatitis B has been significantly reduced but the death rate of patients with advanced stage is still as high as about 60 especially when liver failure is combined with other complications such as This study focuses on the impact of secondary infections on the clinical prognosis of severe hepatitis liver failure and intends to establish a prospective multi-center clinical cohort of secondary infections in liver failure map the infectious pathogens correlate the basic immune status with the characteristics of the pathogen profile of the secondary infections and establish a monitoring and early-warning system of secondary infections so as to explore safe and effective treatment modalities To further reduce the mortality rate of liver failure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None