Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06272266
Status:
COMPLETED
Last Update Posted:
2024-02-22
First Post:
2022-04-06
Brief Title:
The Aerobic Exercise Capacity and Muscle Strenght in Individuals With COVID-19
Sponsor:
Selda Sarıkaya
Organization:
Bulent Ecevit University
Study Overview
Official Title:
Determination of Exercise Capacity and Muscle Strenght in Individuals With COVID-19 the Effect of Aerobic Exercise Training
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The subject of the project is the impact of COVID-19 on the exercise capacity of patients The long-term sequelae of COVID-19 infection are still unknown It is not yet clear whether pulmonary sequelae which may be a consequence of the disease are associated with a measurable functional deficit In this project the aerobic capacity of healthy people will be compared with individuals who have experienced Covid-19 and the amount of increase in aerobic capacity will be determined at the end of 15 sessions by applying a rehabilitation program including bicycle ergometry to individuals who have experienced Covid-19 Detailed description In December 2020 in the pneumonia epidemic in which the city of Wuhan China is the center pneumonia developed due to the newly defined SARS-CoV-2 factor was defined as Coronavirus disease 2019 COVID-19 It has been observed that clinical findings of SARS-CoV-2 infection in patients hospitalized in Wuhan range from mild manifestations such as asymptomatic disease and mild upper respiratory tract infection to severe viral pneumonia accompanied by respiratory failure and may result in deathThe long-term sequelae of COVID19 are still unknown Pulmonary sequelae that impair physical fitness have been predominantly defined for hospitalized patients with COVID-19 Although lung lesions have been identified as asymptomatically in infected individuals it is not yet clear whether these observations are related to a measurable functional deficit in physical fitness They measured the change in the predicted maximum aerobic capacity VO2 max of non-infectedasymptomatically infected and recovering COVID-19 individuals with a well-established and validated physical fitness test before and after the COVID-19 outbreak among young Swiss adultsThey demonstrated decreased aerobic capacity in young adults 1 to 2 months after symptomatic COVID-19 without physical strength being affected In their study 19 of young adults who recovered after COVID-19 had a VO2 max decrease of more than 10 compared to baseline before infection It has been identified that decreased VO2 max value is the hallmark of interstitial lung disease SARS-CoV-2 infection causes lung damage even in asymptomatic cases
A total of 64 people including 32 people in 2 groups between the ages of 18-55 who have or have not had corona virus infection who applied to Bülent Ecevit University Faculty of Medicine Physical Therapy and Rehabilitation or Infectious Diseases outpatient clinics for different reasons will be included in our project The research start date is February 2021 and the end date is February 2023 At the beginning of the study demographic information of the individuals such as gender ageheight weight occupation education body mass index physical activity level international physical activity index-IPAQ the most used hand dominant hand in daily life activities will be recorded In the control group resting heart rate blood pressure saturation measurement ECG will be performed before exercise In addition in order to evaluate their muscle strength microFET3 manual muscle measurement device will be used to measure the triceps muscle strength in the upper extremity they actively use and the quadriceps muscle strength of the same side will be measured and their grip strength will be measured with the JAMAR hydraulic hand dynamometer Using the international physical activity indexIPAQ activity status in daily life will be assessed The exercise capacity of all individuals will be measured with the aid of the COSMED Quark CPET device using the bicycle ergometry test recommended by the American Society of Cardiovascular and Pulmonary Rehabilitation In this test submaximal exercise test will be performed by providing 25 W increase in 2 minutes periods after the warm-up period at 0 load W for 2 minutes In addition the borg scale obtained at the end of the test metabolic equivalent of task MET and maximum work W test duration maximum heart rate parameters will also be recorded in order to evaluate the exercise capacity
Individuals who have been confirmed by the previous SARS-COV 2 real-time reverse transcriptase polymerase chain reaction RT-PCR test to have coronovirus infection after the test will be included in a treatment program of 15 sessions at least 3 sessions per week with bicycle ergometry After 15 sessions exercise capacity will be re-evaluated using the cycling test the aforementioned triceps and grip muscle strengths V02 max maximum conjugate MET maximum work w borg scale maximum heart rate test time parameters will be saved again after treatment
A total of 64 people including 32 people in 2 groups between the ages of 18-55 who have or have not had corona virus infection who applied to Bülent Ecevit University Faculty of Medicine Physical Therapy and Rehabilitation or Infectious Diseases outpatient clinics for different reasons will be included in our project The research start date is February 2021 and the end date is February 2023 At the beginning of the study demographic information of the individuals such as gender ageheight weight occupation education body mass index physical activity level international physical activity index-IPAQ the most used hand dominant hand in daily life activities will be recorded In the control group resting heart rate blood pressure saturation measurement ECG will be performed before exercise In addition in order to evaluate their muscle strength microFET3 manual muscle measurement device will be used to measure the triceps muscle strength in the upper extremity they actively use and the quadriceps muscle strength of the same side will be measured and their grip strength will be measured with the JAMAR hydraulic hand dynamometer Using the international physical activity indexIPAQ activity status in daily life will be assessed The exercise capacity of all individuals will be measured with the aid of the COSMED Quark CPET device using the bicycle ergometry test recommended by the American Society of Cardiovascular and Pulmonary Rehabilitation In this test submaximal exercise test will be performed by providing 25 W increase in 2 minutes periods after the warm-up period at 0 load W for 2 minutes In addition the borg scale obtained at the end of the test metabolic equivalent of task MET and maximum work W test duration maximum heart rate parameters will also be recorded in order to evaluate the exercise capacity
Individuals who have been confirmed by the previous SARS-COV 2 real-time reverse transcriptase polymerase chain reaction RT-PCR test to have coronovirus infection after the test will be included in a treatment program of 15 sessions at least 3 sessions per week with bicycle ergometry After 15 sessions exercise capacity will be re-evaluated using the cycling test the aforementioned triceps and grip muscle strengths V02 max maximum conjugate MET maximum work w borg scale maximum heart rate test time parameters will be saved again after treatment
Detailed Description:
The cardiopulmonary exercise test was also performed on 14 individuals from the control group and 15 individuals in the patient group and by this test the respiratory exchange ratio RER anaerobic threshold AT maximum oxygen capacity VO 2peak maximum ventilatory capacity at anaerobic threshold VO 2AT carbon dioxide ventilatory equivalent VECO 2 heart rate recovery HRR and heart rate recovery at 1 min HRR1 parameters were evaluated The test was repeated after 15 sessions of aerobic exercise training for the individuals in the COVID-19 group who participated in the cardiopulmonary exercise test and the patients were evaluated using the same parameters
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None