Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005333
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Epidemic Hypertension in Nigerian Workers
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Originally from 1991 to 1991 to test the hypothesis that differences in hypertension prevalence in Nigerian workers were primarily related to differences in socioeconomic status SES At renewal in 1996 to determine the importance of weight gain and weight-related factors in blood pressure
Detailed Description:
BACKGROUND
This dynamic population provided a valuable opportunity to gain important information about the etiology of hypertension which would be much more difficult to gain from a United States Black population because higher weight and blood pressure are already entrenched and static in the United States population
DESIGN NARRATIVE
From 1991 to 1996 a cross-sectional study was conducted to test the hypothesis that differences in hypertension prevalence were primarily related to differences in SES The higher prevalence of hypertension among the high SES Nigerian professionals was thought to be related to higher weight caloric intake Westernization of diet alcohol intake sodium intake cardiovascular reactivity and stress due to job migration and change in SES and to reduced potassium intake and physical activity Civil servants were systematically sampled from civil service employee lists Data were collected on blood pressure urinary sodium potassium and protein diet anthropometry electrocardiogram serum insulin stress in the work environment migration history and cardiovascular reactivity
In FY 1992 the Office of Research on Womens Health provided supplemental funds to enlarge the study and to perform gender analyses The supplemental funds were used to determine whether fatty acid distributions and their relationships to cardiovascular risk factors differed between Nigerian women and United States Black women United States Black women and United States white women and Nigerian women and Nigerian men Forty men and forty women ages 18 to 30 were chosen randomly from the Nigerian civil servant population Subjects with hypertension those using oral contraceptives or any medication affecting the sympathetic nervous system were excluded The Nigerian subjects were compared with 40 Black and 40 white healthy female volunteers at the University of Pittsburgh
The grant was renewed in 1996 through August 2001 to conduct a longitudinal study of 726 members of the original cohort The purpose was to determine the importance of weight gain and weight-related factors and the possible interaction of other factors eg psychosocial electrolytes reactivity macronutrient intake to change in blood pressure Factors related to weight gain were identified The high prevalence of the electrocardiogram left ventricular hypertrophy ECG-LVH was validated against echocardiographic measures ECHO-LVH Predictors of change in ECG-LVH and the correlates of microalbuminuria were identified In Year 2 Cohort Year 4 half of the population was restudied with echocardiography cardiovascular reactivity and new psychosocial measures In Year 4 Cohort Year 6 with the exception of cardiovascular reactivity the full cohort was re-examined for baseline measures including multiple blood pressure readings height weight waist hips ECG physical activity two 24 hour dietary recalls alcohol intake menopausal status psychosocial measures 24 hour urine for sodium potassium creatinine micro-albuminuria and fasting serum for lipids insulin glucose and creatinine
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
This dynamic population provided a valuable opportunity to gain important information about the etiology of hypertension which would be much more difficult to gain from a United States Black population because higher weight and blood pressure are already entrenched and static in the United States population
DESIGN NARRATIVE
From 1991 to 1996 a cross-sectional study was conducted to test the hypothesis that differences in hypertension prevalence were primarily related to differences in SES The higher prevalence of hypertension among the high SES Nigerian professionals was thought to be related to higher weight caloric intake Westernization of diet alcohol intake sodium intake cardiovascular reactivity and stress due to job migration and change in SES and to reduced potassium intake and physical activity Civil servants were systematically sampled from civil service employee lists Data were collected on blood pressure urinary sodium potassium and protein diet anthropometry electrocardiogram serum insulin stress in the work environment migration history and cardiovascular reactivity
In FY 1992 the Office of Research on Womens Health provided supplemental funds to enlarge the study and to perform gender analyses The supplemental funds were used to determine whether fatty acid distributions and their relationships to cardiovascular risk factors differed between Nigerian women and United States Black women United States Black women and United States white women and Nigerian women and Nigerian men Forty men and forty women ages 18 to 30 were chosen randomly from the Nigerian civil servant population Subjects with hypertension those using oral contraceptives or any medication affecting the sympathetic nervous system were excluded The Nigerian subjects were compared with 40 Black and 40 white healthy female volunteers at the University of Pittsburgh
The grant was renewed in 1996 through August 2001 to conduct a longitudinal study of 726 members of the original cohort The purpose was to determine the importance of weight gain and weight-related factors and the possible interaction of other factors eg psychosocial electrolytes reactivity macronutrient intake to change in blood pressure Factors related to weight gain were identified The high prevalence of the electrocardiogram left ventricular hypertrophy ECG-LVH was validated against echocardiographic measures ECHO-LVH Predictors of change in ECG-LVH and the correlates of microalbuminuria were identified In Year 2 Cohort Year 4 half of the population was restudied with echocardiography cardiovascular reactivity and new psychosocial measures In Year 4 Cohort Year 6 with the exception of cardiovascular reactivity the full cohort was re-examined for baseline measures including multiple blood pressure readings height weight waist hips ECG physical activity two 24 hour dietary recalls alcohol intake menopausal status psychosocial measures 24 hour urine for sodium potassium creatinine micro-albuminuria and fasting serum for lipids insulin glucose and creatinine
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL044413 | NIH | None | httpsreporternihgovquickSearchR01HL044413 |