Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06270524
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-26
First Post:
2024-02-14
Brief Title:
Study of the C5aC5aR1 Axis in IgG4-associated Disease a Potential Therapeutic Target
Sponsor:
Assistance Publique Hopitaux De Marseille
Organization:
Assistance Publique Hopitaux De Marseille
Study Overview
Official Title:
Pilot Study of the C5aC5aR1 Axis in IgG4-associated Disease a Potential Therapeutic Target C5-MAG4 Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
C5-MAG4
Brief Summary:
This is a monocentric comparative cross-sectional case-control study seeking to identify abnormalities of the C5a-C5aR1 axis between a population of patients with active IgG4-associated disease MAG4 and two control groups healthy subjects without MAG4 and patients with MAG4 in remission
Detailed Description:
IgG4-associated disease is a rare fibrosing and inflammatory disorder whose pathophysiology remains poorly understood Activation of certain monocytemacrophage populations in particular M2-type macrophages has been shown to be involved during the course of the disease The mechanisms behind this monocytemacrophage activation are not known Expression of the C5aR receptor on the surface of these populations and preliminary findings of elevated C5a in these patients suggest a potential role for this C5a-C5aR axis Demonstration of the involvement of this pathway would open a path to therapeutic perspetives C5aR inhibitors for these patients who frequently suffer from cortico-dependence and relapses The aim of this research is to use healthcare technologies to identify cellular and molecular therapeutic targets in the context of the IgG4-associated disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None