Ignite Creation Date:
2024-05-06 @ 8:10 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06272357
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-22
First Post:
2023-11-23
Brief Title:
The Use of Antiarrhythmic Drugs in Pediatrics
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Clinical Audit on the Use of Antiarrhythmic Drugs in Pediatric Age Group
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A study on the use of antiarrhythmic drugs in pediatric age group in Assiut University Childrens Hospital a clinical audit
Detailed Description:
Arrhythmias occur in children and adolescents with congenital heart disease as well as those with structurally normal hearts
Rhythm disturbances arrhythmias are not uncommon in sick children admitted in pediatric intensive care unit These occur as a result of abnormalities in or insults to the cardiac conduction system or heart tissues A rhythm disturbance in a child should be treated as life threatening emergency
The generation of the action potential and the regional differences that are observed throughout the heart are the result of the selective permeability of ion channels distributed on the cell membrane
Abnormalities in surface membrane ion channel function are central to arrhythmogenesis
Antiarrhythmic medications primarily affect the ion channels in cardiac myocytes that are responsible for generating currents that create the action potential
By altering the activity of these ion channels the action potential is changed to reduce the likelihood of sustained arrhythmias
These drugs are predominantly used in treatment of arrhythmia but in addition they are also used as a treatment of other cardiac and non-cardiac conditions
For example Calcium channel blockers have been one of the most widely used classes of antihypertensive agents in the last 20 years
Carvedilol a beta blocker agent can be safely used for treatment of chronic heart dysfunction in pediatric patients with dilated cardiomyopathy
β-blockers are also an essential component of pharmacologic therapy for children with congestive heart failure
There is a wide range of antiarrhythmic drugs used in treatment of arrhythmias The modernized comprehensive classification of both established and potential antiarrhythmic drugs was proposed in 2018 Class 0 HCN channel-mediated pacemaker current If block Class I Antiarrhythmic that affect sodium channels slow depolarization Class II Drugs that counteract the sympathetic nervous system predominantly beta-blockers Class III drugs that affect the potassium channels prolong repolarization Class IV Drugs that affect calcium channels Calcium channel blockers Class V mechanically sensitive ion channels Mechanosensitive channel blockers Class VI Gap junction channel blockers Class VII Upstream target modulators
In this study the aim is to describe the use of Cardiovascular Drugs in Pediatric Cardiology unit Assiut University As regard indications of use proper dosage and proper management of side effects of their use
Rhythm disturbances arrhythmias are not uncommon in sick children admitted in pediatric intensive care unit These occur as a result of abnormalities in or insults to the cardiac conduction system or heart tissues A rhythm disturbance in a child should be treated as life threatening emergency
The generation of the action potential and the regional differences that are observed throughout the heart are the result of the selective permeability of ion channels distributed on the cell membrane
Abnormalities in surface membrane ion channel function are central to arrhythmogenesis
Antiarrhythmic medications primarily affect the ion channels in cardiac myocytes that are responsible for generating currents that create the action potential
By altering the activity of these ion channels the action potential is changed to reduce the likelihood of sustained arrhythmias
These drugs are predominantly used in treatment of arrhythmia but in addition they are also used as a treatment of other cardiac and non-cardiac conditions
For example Calcium channel blockers have been one of the most widely used classes of antihypertensive agents in the last 20 years
Carvedilol a beta blocker agent can be safely used for treatment of chronic heart dysfunction in pediatric patients with dilated cardiomyopathy
β-blockers are also an essential component of pharmacologic therapy for children with congestive heart failure
There is a wide range of antiarrhythmic drugs used in treatment of arrhythmias The modernized comprehensive classification of both established and potential antiarrhythmic drugs was proposed in 2018 Class 0 HCN channel-mediated pacemaker current If block Class I Antiarrhythmic that affect sodium channels slow depolarization Class II Drugs that counteract the sympathetic nervous system predominantly beta-blockers Class III drugs that affect the potassium channels prolong repolarization Class IV Drugs that affect calcium channels Calcium channel blockers Class V mechanically sensitive ion channels Mechanosensitive channel blockers Class VI Gap junction channel blockers Class VII Upstream target modulators
In this study the aim is to describe the use of Cardiovascular Drugs in Pediatric Cardiology unit Assiut University As regard indications of use proper dosage and proper management of side effects of their use
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None