Ignite Creation Date:
2024-05-06 @ 8:10 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06289777
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-04
First Post:
2024-02-17
Brief Title:
Aortic Remodeling After Endovascular Management of Type B Aortic Dissection
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Aortic Remodeling After Endovascular Management of Type B Aortic Dissection
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Assess the clinical outcome morphological changes and behaviour of type B aortic dissection after endovascular repair
Detailed Description:
Aortic dissection AD is considered the most common catastrophic event of the aorta and its incidence has been reported to be 3100000 per year exceeding that of ruptured abdominal aortic aneurysm
AD is a dynamic process and can occur anywhere along the course of the aorta with the pathognomonic lesion being an intimal tear followed by blood surging either antegrade typically or retrograde cleaving the the intima and medial layers of the aortic wall longitudinally for a variable distance thus creating a true and false lumens
Aortic dissections are classified by chronicity anatomic location of false lumen generally the entry tear and longitudinal extent and the presence or absence of complicating features
Temporally AD is categorized as acute phase 14 days subacute 15-90 days and chronic 90 days
Thoracic Endovascular Aortic Repair TEVAR has emerged as the first-line therapy for the treatment of AD with better short-term results than open repair due to a significant decrease in perioperative morbidity and mortality
By covering the primary entry tear with stent-grafts the blood flow is redirected into the true lumen resolving malperfusion andor preventing rupture of the false lumen followed by its regression and re-expansion of the true lumen which is known as Aortic remodeling
AD is a dynamic process and can occur anywhere along the course of the aorta with the pathognomonic lesion being an intimal tear followed by blood surging either antegrade typically or retrograde cleaving the the intima and medial layers of the aortic wall longitudinally for a variable distance thus creating a true and false lumens
Aortic dissections are classified by chronicity anatomic location of false lumen generally the entry tear and longitudinal extent and the presence or absence of complicating features
Temporally AD is categorized as acute phase 14 days subacute 15-90 days and chronic 90 days
Thoracic Endovascular Aortic Repair TEVAR has emerged as the first-line therapy for the treatment of AD with better short-term results than open repair due to a significant decrease in perioperative morbidity and mortality
By covering the primary entry tear with stent-grafts the blood flow is redirected into the true lumen resolving malperfusion andor preventing rupture of the false lumen followed by its regression and re-expansion of the true lumen which is known as Aortic remodeling
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None