Ignite Creation Date:
2024-05-06 @ 8:10 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06281795
Status:
RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-02-19
Brief Title:
Neuromodulation of the Autonomic Nervous System in Athletes
Sponsor:
Bakulev Scientific Center of Cardiovascular Surgery
Organization:
Bakulev Scientific Center of Cardiovascular Surgery
Study Overview
Official Title:
Neuromodulation of the Autonomic Nervous System in Athletes NANSA Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NANSA
Brief Summary:
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes to accelerate recovery after physical exertion It has been demonstrated that tVNS in athletes improved the rate of heart rate recovery reduced lactic acid levels in blood plasma reduced pain reduced overtraining syndrome and fatigue levels
Detailed Description:
Several studies have shown that transcutaneous vagus nerve stimulation tVNS potentially exhibits therapeutic effects similar to its invasive counterpart tVNS is performed using surface electrodes and low-frequency electrical currents targeting specific locations most commonly the auricular branch of the vagus nerve or its cervical branch
Stimulation of the auricular branch of the vagus nerve activates vagal sensory fibers simulating sensory input to the brainstem and forming what is known as the auriculo-vagal afferent pathway Since these fibers project directly to the nucleus of the solitary tract also known as the solitary tract nucleus which in turn has direct or indirect projections to nuclei that provide noradrenergic endorphinergic and serotonergic fibers in various parts of the brain regulating systemic parameters of cardiovascular respiratory and immune functions it can be expected that the bodys response to stimulation of the auricular branch of the vagus nerve will be systemic
With the onset of physical exercise sympathetic activity in the body increases and reaches a plateau value after a certain period of maximum activity After the end of physical exercise suppressed parasympathetic activity begins to intensify and the sympathetic system gradually returns to a resting state After training parasympathetic system activation continues for up to 48 hours In certain types of training when the frequency of anaerobic respiration increases during physical exertion a decrease in parasympathetic reactivation may be observed
In the literature there are individual studies that have evaluated the effects of transcutaneous stimulation of the auricular branch of the vagus nerve for sports purposes to accelerate recovery processes after physical exertion It has been demonstrated that tVNS in athletes improves heart rate recovery reduces lactate levels in plasma reduces pain sensations decreases overtraining syndrome and reduces fatigue levels
The aim of this study is to evaluate the influence of low-frequency electrical stimulation of the auricular branch of the vagus nerve on the functional reserve of the cardiovascular and respiratory systems in athletes during the post-training period after high-intensity workouts
Stimulation of the auricular branch of the vagus nerve activates vagal sensory fibers simulating sensory input to the brainstem and forming what is known as the auriculo-vagal afferent pathway Since these fibers project directly to the nucleus of the solitary tract also known as the solitary tract nucleus which in turn has direct or indirect projections to nuclei that provide noradrenergic endorphinergic and serotonergic fibers in various parts of the brain regulating systemic parameters of cardiovascular respiratory and immune functions it can be expected that the bodys response to stimulation of the auricular branch of the vagus nerve will be systemic
With the onset of physical exercise sympathetic activity in the body increases and reaches a plateau value after a certain period of maximum activity After the end of physical exercise suppressed parasympathetic activity begins to intensify and the sympathetic system gradually returns to a resting state After training parasympathetic system activation continues for up to 48 hours In certain types of training when the frequency of anaerobic respiration increases during physical exertion a decrease in parasympathetic reactivation may be observed
In the literature there are individual studies that have evaluated the effects of transcutaneous stimulation of the auricular branch of the vagus nerve for sports purposes to accelerate recovery processes after physical exertion It has been demonstrated that tVNS in athletes improves heart rate recovery reduces lactate levels in plasma reduces pain sensations decreases overtraining syndrome and reduces fatigue levels
The aim of this study is to evaluate the influence of low-frequency electrical stimulation of the auricular branch of the vagus nerve on the functional reserve of the cardiovascular and respiratory systems in athletes during the post-training period after high-intensity workouts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None