Ignite Creation Date:
2024-05-06 @ 8:10 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06281275
Status:
RECRUITING
Last Update Posted:
2024-06-21
First Post:
2024-02-20
Brief Title:
A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients
Sponsor:
Huazhong University of Science and Technology
Organization:
Huazhong University of Science and Technology
Study Overview
Official Title:
A Study on the Association Between Frailty and Acute Postoperative Pain in Elderly Patients Undergoing Thoracoscopic Surgery and an Investigation of the Mechanisms Involved
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients and consequently improve their quality of life and mental status
Detailed Description:
Frailty as a geriatric syndrome is recognized as being characterized by a decline in the reserve capacity of the bodys physiological systems1 and in severe cases by regulatory disorders which result in a decrease in the individuals resistance and resilience to a variety of contingency sources including organismal physiological and psychological stressors as well as an increase in organismal susceptibility to damage The globe is accelerating its entry into an aging society and according to the World Health Organizations report on aging and health reports the proportion of the worlds population over the age of 60 will increase from 12 to 22 between 2015 and 2050 As the population ages the prevalence of frailty in healthy populations increases exponentially with age The prevalence in healthy populations ranges from 65 in healthy people between the ages of 60-69 years to as high as 65 or even higher in healthy people over the age of 85 years The prevalence of frailty in healthy populations has been shown to increase with age
Frailty is now an emerging global health burden with a meta-analysis of studies from 62 countries noting a 24 prevalence of frailty and a 49 prevalence of pre-frailty in people over the age of 50 Frailty typically prolongs hospital stays and increases hospitalization costs for older patients increases the prevalence of depression and the risk of cardiovascular disease increases intraoperative blood loss in patients and even leads to an increased risk of new-onset disability and death in individuals Frailty has been shown to increase the risk of new-onset disability death in individuals and intraoperative blood loss in patients Frailty can even lead to an increased risk of new-onset disability and death in individuals
Currently the proportion of elderly patients undergoing surgery is also increasing With the development of minimally invasive surgery more and more thoracic surgical diseases are treated with thoracoscopic surgery which is characterized by smaller incisions less trauma better results and the promotion of rapid recovery compared with open thoracic surgery Despite the rapid and minimally invasive development of thoracic surgery postoperative pain after lung surgery is severe and patients in the first few hours after surgery may still experience severe pain Postoperative pain can lead to adverse consequences such as decreased quality of life and impact on physical and mental health Some studies have shown that older adults with early-onset debility have a high prevalence of chronic pain and risk factors for the development of debility include the prolonged presence of pain Thus there may be an unproven bidirectional relationship between debility and pain
Currently the mechanisms of the development of frailty are unknown and Frailty is associated with gut microbiota and biomarkers Therefore a clear understanding of the association between frailty and acute postoperative pain in elderly thoracoscopic surgery patients and its underlying mechanisms is essential to reduce the level of acute postoperative pain and improve the frailty status of elderly thoracoscopic surgery patients but also important to improve their quality of life and mental status
Frailty is now an emerging global health burden with a meta-analysis of studies from 62 countries noting a 24 prevalence of frailty and a 49 prevalence of pre-frailty in people over the age of 50 Frailty typically prolongs hospital stays and increases hospitalization costs for older patients increases the prevalence of depression and the risk of cardiovascular disease increases intraoperative blood loss in patients and even leads to an increased risk of new-onset disability and death in individuals Frailty has been shown to increase the risk of new-onset disability death in individuals and intraoperative blood loss in patients Frailty can even lead to an increased risk of new-onset disability and death in individuals
Currently the proportion of elderly patients undergoing surgery is also increasing With the development of minimally invasive surgery more and more thoracic surgical diseases are treated with thoracoscopic surgery which is characterized by smaller incisions less trauma better results and the promotion of rapid recovery compared with open thoracic surgery Despite the rapid and minimally invasive development of thoracic surgery postoperative pain after lung surgery is severe and patients in the first few hours after surgery may still experience severe pain Postoperative pain can lead to adverse consequences such as decreased quality of life and impact on physical and mental health Some studies have shown that older adults with early-onset debility have a high prevalence of chronic pain and risk factors for the development of debility include the prolonged presence of pain Thus there may be an unproven bidirectional relationship between debility and pain
Currently the mechanisms of the development of frailty are unknown and Frailty is associated with gut microbiota and biomarkers Therefore a clear understanding of the association between frailty and acute postoperative pain in elderly thoracoscopic surgery patients and its underlying mechanisms is essential to reduce the level of acute postoperative pain and improve the frailty status of elderly thoracoscopic surgery patients but also important to improve their quality of life and mental status
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None