Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06287580
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-06-26
First Post:
2024-02-23
Brief Title:
Effects of Antihypertensive Drug Treatment on Brain Blood Flow Cognition and Regulation of Nervous System in Older Adults with Hypertension
Sponsor:
University of Texas Southwestern Medical Center
Organization:
University of Texas Southwestern Medical Center
Study Overview
Official Title:
Antihypertensive Drug Effects on Cerebral Hemodynamics and Sympathetic Control in Older Hypertensive Patients
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High blood pressure BP is a public health problem worldwide Nearly three-quarters of older adults age 60 years in the United States have high BP High BP links to many health problems like stroke Drug treatments are typically used in clinics to reduce high BP and the risk of associated health problems However these drug treatments may not always benefit brain health For example drug treatment may reduce brain blood flow which may reduce cognitive function in older adults with high BP Alternatively reduced brain blood flow may cause high BP due to increased nervous system activity the so-called fight or flight response Thus monitoring brain blood flow may help to manage high BP during drug treatment
It is unknown if brain blood flow and its control will be altered by drug treatment in older high BP patients Therefore study team will recruit older adults with high BP who receive either drug treatment or a placebo for 2 weeks and will assess brain blood flow cognitive function and nervous system control before and after treatment
Results from this study will provide novel and clinically relevant information on the impact of drug treatment for high BP on brain health Investigators expect these results will suggest that it is crucial to measure brain blood flow which may be a therapeutic new target for BP control and brain health
It is unknown if brain blood flow and its control will be altered by drug treatment in older high BP patients Therefore study team will recruit older adults with high BP who receive either drug treatment or a placebo for 2 weeks and will assess brain blood flow cognitive function and nervous system control before and after treatment
Results from this study will provide novel and clinically relevant information on the impact of drug treatment for high BP on brain health Investigators expect these results will suggest that it is crucial to measure brain blood flow which may be a therapeutic new target for BP control and brain health
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None