Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06288841
Status:
RECRUITING
Last Update Posted:
2024-03-01
First Post:
2024-02-25
Brief Title:
Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients A Randomized Single-blind Active-Controlled Clinical Study
Sponsor:
Tianjin Medical University General Hospital
Organization:
Tianjin Medical University General Hospital
Study Overview
Official Title:
Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients A Randomized Single-blind Active-Controlled Clinical Study
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
With the development of the concept of comfortable medicine and enhanced recovery surgery ERAS optimizing the perioperative management of patients reducing surgical stress and reducing postoperative pain can effectively reduce perioperative complications and achieve the purpose of accelerating recovery As an important part of ERAS multimodal analgesia is the core concept of perioperative analgesia management As a kind of perioperative multimodal analgesia quadratus lumbar muscle block QLB is a type of local anesthetic drug injected around the quadratus lumbar muscle to reduce or eliminate abdominal wall pain and visceral pain after abdominal surgery QLB has been used successfully for pain control after laparoscopic and open surgery reducing perioperative opioid use and improving prognosis-related measures such as PONV and length of hospital stay Bupivacaine liposomes use DepoFoam technology to encapsulate the drug in polycystic liposomes which can prolong the release time of bupivacaine due to the different rupture times of different vesicles and the postoperative analgesia can be up to 72 hours In this project patients who undergo elective laparoscopic uterine and double adnexectomy were selected to be injected with lipososomes of bupivacaine at different concentrations under ultrasound guidance of bilateral posterior QLB before anesthesia induction and the effect of liposomal bupivacaine on postoperative pain was investigated by evaluating the postoperative pain and incidence of adverse events This study will greatly promote the clinical promotion and application of bupivacaine liposome improve the postoperative comfort and satisfaction of patients and accelerate the postoperative recovery of patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None