Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06284382
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-28
First Post:
2024-02-13
Brief Title:
Interaction Between Early Trauma and Odor-induced Dopamine Release
Sponsor:
Hôpital le Vinatier
Organization:
Hôpital le Vinatier
Study Overview
Official Title:
Consequence of Early Trauma on Odor Hedonics Appreciation and DOpamine Release
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
T-ODOR
Brief Summary:
This prospective double-blind parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors
Detailed Description:
The occurrence of early trauma has been linked to alterations in the development of emotion regulation circuits and functional brain connectivity particularly in the dorsolateral prefrontal cortex - DLPFC the dopaminergic response to stress and an alteration in hedonicity including olfactory hedonicity which can lead to the onset of psychiatric disorders such as anxiety or depression
However few studies have investigated the influence of early trauma on the release of dopamine DA evoked by odors with a positive emotional valence Yet hedonicity is a key component of olfaction as a positive odor leads to reinforced behavior in areas such as food intake and social interaction This reinforcement process is thought to be underpinned by the very close link between the olfactory system olfactory tubercle the emotional regulation system DLPFC and the reward system striatum including the release of DA
The aim of the study is to investigate the influence of early trauma on DAergic transmission evoked by odorants with a positive emotional valence
To this end 30 participants will be recruited and divided into two groups those with early trauma and those without according to their score on the Childhood Trauma Questionnaire They will undergo an MRI-PET scan during which they will be exposed to pleasant odors Subcortical dopaminergic transmission will be analyzed using the PET activity of 11CRaclopride a D2 receptor antagonist
Investigators hypothesize that early trauma resulting in abnormal cortico-subcortical and cortico-cortical connectivity would lead to a deficit in the hedonic appreciation of a pleasant odor associated with a reduction in DAergic reactivity evoked in the reward system
However few studies have investigated the influence of early trauma on the release of dopamine DA evoked by odors with a positive emotional valence Yet hedonicity is a key component of olfaction as a positive odor leads to reinforced behavior in areas such as food intake and social interaction This reinforcement process is thought to be underpinned by the very close link between the olfactory system olfactory tubercle the emotional regulation system DLPFC and the reward system striatum including the release of DA
The aim of the study is to investigate the influence of early trauma on DAergic transmission evoked by odorants with a positive emotional valence
To this end 30 participants will be recruited and divided into two groups those with early trauma and those without according to their score on the Childhood Trauma Questionnaire They will undergo an MRI-PET scan during which they will be exposed to pleasant odors Subcortical dopaminergic transmission will be analyzed using the PET activity of 11CRaclopride a D2 receptor antagonist
Investigators hypothesize that early trauma resulting in abnormal cortico-subcortical and cortico-cortical connectivity would lead to a deficit in the hedonic appreciation of a pleasant odor associated with a reduction in DAergic reactivity evoked in the reward system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None