Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06283914
Status:
COMPLETED
Last Update Posted:
2024-06-21
First Post:
2024-02-22
Brief Title:
Imputation of Arterial Oxygen Partial Pressures Using Pulse Oximetry
Sponsor:
American University of Beirut Medical Center
Organization:
American University of Beirut Medical Center
Study Overview
Official Title:
Imputation of Arterial Oxygen Partial Pressures Using Pulse Oximetry in Surgical Patients Under General Anesthesia
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this is prospective cohort study is to to study the relationship between PaO2 and SpO2 in the overall population undergoing general anesthesia in the OT Secondary aims include studying the relationship between PaO2 and SpO2 in elderly and obese patients undergoing general anesthesia in the OT validating the derivation of PaO2 from SpO2 using formulas derived by Rice Pandharipande and Gadrey in patients undergoing general anesthesia in the OT and if the derivation formulas were not valid to derive a formula for patients undergoing general anesthesia in the OT
The included blood samples are arterial blood sample collected for ABGs analysis through either an arterial catheter or an arterial blood puncture in adult patients Age 18 years undergoing general anesthesia regardless of the acuity of the surgery elective emergency or lifesaving the hemodynamic stability of the patient or the comorbidities Patients undergoing cardiac or thoracic surgeries will be excluded
The included blood samples are arterial blood sample collected for ABGs analysis through either an arterial catheter or an arterial blood puncture in adult patients Age 18 years undergoing general anesthesia regardless of the acuity of the surgery elective emergency or lifesaving the hemodynamic stability of the patient or the comorbidities Patients undergoing cardiac or thoracic surgeries will be excluded
Detailed Description:
The partial pressure of oxygen in the arterial blood PaO2 the fraction of inspired oxygen FiO2 ratio has been commonly used as an indicator of adequate oxygenation and in the diagnosis and severity of acute respiratory distress syndrome ARDS which requires arterial blood gas ABGs analysis Another way to measure oxygenation is by using the noninvasive pulse oximetry to measure the oxygen saturation SpO2 Three formulas have been derived and validated in the intensive care unit ICU setting to estimate the PaO2 from the SpO2 However the relationship of PaO2 and SpO2 and these derivation equations are not validated in the setting of general anesthesia in the operating theatre OT in which patients are prone to multiple intraoperative and postoperative pulmonary complications
The aim is to study the relationship between PaO2 and SpO2 in the overall population undergoing general anesthesia in the OT Secondary aims include studying the relationship between PaO2 and SpO2 in elderly and obese patients undergoing general anesthesia in the OT validating the derivation of PaO2 from SpO2 using formulas derived by Rice Pandharipande and Gadrey in patients undergoing general anesthesia in the OT and if the derivation formulas were not valid to derive a formula for patients undergoing general anesthesia in the OT
This is a prospective cohort study that will be conducted at the American University of Beirut Medical Center AUBMC in the OT under the Department of Anesthesiology and Pain Medicine The data will be collected by the investigators of the study from the patients chart on EPIC These include the PaO2 in mmHg FiO2 SpO2 in and Mean airway pressure in cmH2O at the time of sample collection in addition to patient characteristics as age gender weight height BMI smoking status surgery type surgery acuity and present comorbidities specifically cardiac and respiratory comorbidities
Validating the use of one of the formulas to derive PaO2 from SpO2 in the OT would help anesthesiologists detect derangements in patients oxygenation earlier and decrease the need for ABGs analysis and its possible complications
The aim is to study the relationship between PaO2 and SpO2 in the overall population undergoing general anesthesia in the OT Secondary aims include studying the relationship between PaO2 and SpO2 in elderly and obese patients undergoing general anesthesia in the OT validating the derivation of PaO2 from SpO2 using formulas derived by Rice Pandharipande and Gadrey in patients undergoing general anesthesia in the OT and if the derivation formulas were not valid to derive a formula for patients undergoing general anesthesia in the OT
This is a prospective cohort study that will be conducted at the American University of Beirut Medical Center AUBMC in the OT under the Department of Anesthesiology and Pain Medicine The data will be collected by the investigators of the study from the patients chart on EPIC These include the PaO2 in mmHg FiO2 SpO2 in and Mean airway pressure in cmH2O at the time of sample collection in addition to patient characteristics as age gender weight height BMI smoking status surgery type surgery acuity and present comorbidities specifically cardiac and respiratory comorbidities
Validating the use of one of the formulas to derive PaO2 from SpO2 in the OT would help anesthesiologists detect derangements in patients oxygenation earlier and decrease the need for ABGs analysis and its possible complications
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None