Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06288308
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-01
First Post:
2023-11-12
Brief Title:
Fibrinogen to Albumin Ratio FAR as a Predictive Biomarker for Lupus Nephritis LN
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Fibrinogen to Albumin Ratio as a Predictive Biomarker for Lupus Nephritis LN
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Fibrinogen to Albumin ratio as a predictive biomarker for lupus nephritis LN
Detailed Description:
Systemic lupus erythematosus is a chronic autoimmune disease often coexists with other diseases and damages multiple organs such as kidney liver nervous system and so on
Lupus nephritis is clinically evident in 50-60 of patients with systemic lupus erythematosus and it is histologically evident in most SLE patients even those without clinical manifestations of kidney disease
The current standardized classification system for lupus nephritis is derived from the World Health Organization and the International Society of NephrologyRenal Pathology Societys recommendations The classification system is based on glomerular morphologic changes seen on microscopy immune deposits seen on immunofluorescence and also electronic microscopy
Class 1 - Minimal Mesangial Lupus Nephritis Class 2 - Mesangial Proliferative Lupus Nephritis Class 3 - Focal Lupus Nephritis Class 4 - Diffuse Lupus Nephritis Class 5 - Membranous Lupus Nephritis Class 6 - Advanced Sclerosis Lupus Nephritis Fibrinogen FIB is an acute time response protein rises rapidly in inflammation infection myocardial infarction and tumor The formation and deposition of immune complexes are important mechanism of lupus nephritis the infiltrate of inflammatory cells and the release of inflammatory factors cause renal injury resulting in the decreasing concentration of albumin The fibrinogen-to-albumin ratio as a new inflammatory marker has been proved to have good predictive value in the diagnosis and prognosis of diabetic nephropathy acute renal injury SLE disease and so on
Lupus nephritis is clinically evident in 50-60 of patients with systemic lupus erythematosus and it is histologically evident in most SLE patients even those without clinical manifestations of kidney disease
The current standardized classification system for lupus nephritis is derived from the World Health Organization and the International Society of NephrologyRenal Pathology Societys recommendations The classification system is based on glomerular morphologic changes seen on microscopy immune deposits seen on immunofluorescence and also electronic microscopy
Class 1 - Minimal Mesangial Lupus Nephritis Class 2 - Mesangial Proliferative Lupus Nephritis Class 3 - Focal Lupus Nephritis Class 4 - Diffuse Lupus Nephritis Class 5 - Membranous Lupus Nephritis Class 6 - Advanced Sclerosis Lupus Nephritis Fibrinogen FIB is an acute time response protein rises rapidly in inflammation infection myocardial infarction and tumor The formation and deposition of immune complexes are important mechanism of lupus nephritis the infiltrate of inflammatory cells and the release of inflammatory factors cause renal injury resulting in the decreasing concentration of albumin The fibrinogen-to-albumin ratio as a new inflammatory marker has been proved to have good predictive value in the diagnosis and prognosis of diabetic nephropathy acute renal injury SLE disease and so on
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None